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  <xs:element id="huma_AHACMember" abstract="true" name="AHACMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_OptionAgreementSharesAuthorizedForIssuanceValue" abstract="false" name="OptionAgreementSharesAuthorizedForIssuanceValue" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_SubsequentInstallmentThreeMember" abstract="true" name="SubsequentInstallmentThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_TubularProsthesesPatentRightsMember" abstract="true" name="TubularProsthesesPatentRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_PaymentsOfTransactionCosts" abstract="false" name="PaymentsOfTransactionCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember" abstract="true" name="SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_CARESActEmployeeRetentionCreditReceivable" abstract="false" name="CARESActEmployeeRetentionCreditReceivable" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_WarrantsAndRightsOutstandingPolicyPolicyTextBlock" abstract="false" name="WarrantsAndRightsOutstandingPolicyPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="huma_EmbeddedDerivativeFinancialInstrumentsRevenueInterestPurchaseAgreementMember" abstract="true" name="EmbeddedDerivativeFinancialInstrumentsRevenueInterestPurchaseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePeriodThreeMember" abstract="true" name="DebtInstrumentPrepaymentFeePeriodThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_ClassOfWarrantOrRightWarrantsExercisableImmediately" abstract="false" name="ClassOfWarrantOrRightWarrantsExercisableImmediately" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilityShares" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilityShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_PeriodThreeMember" abstract="true" name="PeriodThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_DebtInstrumentFinalPaymentAmount" abstract="false" name="DebtInstrumentFinalPaymentAmount" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_CommonStockReservedForOptionAgreementMember" abstract="true" name="CommonStockReservedForOptionAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="huma_CollaborativeArrangementMaximumAnnualMaintenanceFee" abstract="false" name="CollaborativeArrangementMaximumAnnualMaintenanceFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_AssumptionOfPubliclyTradedSecuritiesMember" abstract="true" name="AssumptionOfPubliclyTradedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePercent" abstract="false" name="DebtInstrumentPrepaymentFeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="huma_PercentageOfCumulativePurchaserPaymentsLessTotalRevenueInterestPaymentsDue" abstract="false" name="PercentageOfCumulativePurchaserPaymentsLessTotalRevenueInterestPaymentsDue" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="huma_CollaborativeArrangementExpirationPeriod" abstract="false" name="CollaborativeArrangementExpirationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilityPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="huma_ContingentConsiderationTrancheOneMember" abstract="true" name="ContingentConsiderationTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_PaymentsForClinicalResearchServices" abstract="false" name="PaymentsForClinicalResearchServices" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_HumacyteIncMember" abstract="true" name="HumacyteIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_FrenovaRenalResearchMember" abstract="true" name="FrenovaRenalResearchMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CollaborativeArrangementMilestonePaymentsDomain" abstract="true" name="CollaborativeArrangementMilestonePaymentsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_OtherRelatedPartyExpensesMember" abstract="true" name="OtherRelatedPartyExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_EarnoutSharesMember" abstract="true" name="EarnoutSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePeriodDomain" abstract="true" name="DebtInstrumentPrepaymentFeePeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_RoyaltyPercentageOfAnnualNetSalesPayable" abstract="false" name="RoyaltyPercentageOfAnnualNetSalesPayable" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="huma_NoncashContingentDerivativeLiability" abstract="false" name="NoncashContingentDerivativeLiability" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_SubsequentInstallmentTwoMember" abstract="true" name="SubsequentInstallmentTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="huma_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock" abstract="false" name="ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:textBlockItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePeriodAxis" abstract="true" name="DebtInstrumentPrepaymentFeePeriodAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent" abstract="false" name="AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_DebtInstrumentFinalPaymentFeePercent" abstract="false" name="DebtInstrumentFinalPaymentFeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="huma_RevenueInterestLiabilityActivityRollForward" abstract="true" name="RevenueInterestLiabilityActivityRollForward" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="huma_PercentageThresholdOfCumulativePurchaserPaymentsRequiredForDiscontinuanceOfRevenueInterestPayments" abstract="false" name="PercentageThresholdOfCumulativePurchaserPaymentsRequiredForDiscontinuanceOfRevenueInterestPayments" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:pureItemType"/>
  <xs:element id="huma_SharesAvailableForGrantUnderESPPMember" abstract="true" name="SharesAvailableForGrantUnderESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="huma_SmallDiameterVesselLicenseAgreementMember" abstract="true" name="SmallDiameterVesselLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_TubularProsthesisLicenseAgreementMember" abstract="true" name="TubularProsthesisLicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DistributionAgreementTerminationPeriod" abstract="false" name="DistributionAgreementTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
</xs:schema>
