<?xml version="1.0" encoding="UTF-8"?>

<!--XBRL Document Created with Wdesk from Workiva-->
<!--Copyright 2022 Workiva-->
<!--r:8b07d5ca-a1e8-49ab-a93c-1566bd43f17e,g:5383a2c4-bbe0-41fb-ba08-985e908bb8e5-->
<link:linkbase xmlns:link="http://www.xbrl.org/2003/linkbase" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xsi:schemaLocation="http://www.xbrl.org/2003/linkbase http://www.xbrl.org/2003/xbrl-linkbase-2003-12-31.xsd">
  <link:roleRef roleURI="http://www.humacyte.com/role/CoverPage" xlink:type="simple" xlink:href="huma-20220630.xsd#CoverPage"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CoverPage" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_dei_CoverAbstract_4a2f63de-8728-4d9e-96a7-b358260548f3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CoverAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationTable_67872463-5787-4af9-a31e-c14827715b17" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_CoverAbstract_4a2f63de-8728-4d9e-96a7-b358260548f3" xlink:to="loc_dei_DocumentInformationTable_67872463-5787-4af9-a31e-c14827715b17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_2ed51bce-45c9-4f5d-b951-a348b1e8ee5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_67872463-5787-4af9-a31e-c14827715b17" xlink:to="loc_us-gaap_StatementClassOfStockAxis_2ed51bce-45c9-4f5d-b951-a348b1e8ee5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_7b47d01d-3729-4b5a-be1b-218debeef4ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_2ed51bce-45c9-4f5d-b951-a348b1e8ee5e" xlink:to="loc_us-gaap_ClassOfStockDomain_7b47d01d-3729-4b5a-be1b-218debeef4ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_fdc5216e-74c3-430b-bf46-285ec2229a45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_7b47d01d-3729-4b5a-be1b-218debeef4ec" xlink:to="loc_us-gaap_CommonStockMember_fdc5216e-74c3-430b-bf46-285ec2229a45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfCommonStockAtAnExercisePriceOf1150Member_6ef21609-5950-40eb-8dca-59c4caa7f1fc" xlink:href="huma-20220630.xsd#huma_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfCommonStockAtAnExercisePriceOf1150Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_7b47d01d-3729-4b5a-be1b-218debeef4ec" xlink:to="loc_huma_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfCommonStockAtAnExercisePriceOf1150Member_6ef21609-5950-40eb-8dca-59c4caa7f1fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentInformationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationTable_67872463-5787-4af9-a31e-c14827715b17" xlink:to="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentType_f74973b2-0d03-4943-8f81-72384de54a51" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentType"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentType_f74973b2-0d03-4943-8f81-72384de54a51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentQuarterlyReport_5925f355-3bb7-4892-8c0a-a2ff28383dc0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentQuarterlyReport"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentQuarterlyReport_5925f355-3bb7-4892-8c0a-a2ff28383dc0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentPeriodEndDate_96771d4d-f756-47f9-b357-96d137748b90" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentPeriodEndDate"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentPeriodEndDate_96771d4d-f756-47f9-b357-96d137748b90" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentTransitionReport_25e8ac06-4b4d-489d-a430-bc671be92c57" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentTransitionReport"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentTransitionReport_25e8ac06-4b4d-489d-a430-bc671be92c57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFileNumber_3d5f553f-1981-4ab5-8833-2f00dd346390" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFileNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityFileNumber_3d5f553f-1981-4ab5-8833-2f00dd346390" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityRegistrantName_fa7295c5-27a8-485f-bf2b-01500b0e1d8b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityRegistrantName"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityRegistrantName_fa7295c5-27a8-485f-bf2b-01500b0e1d8b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityIncorporationStateCountryCode_cc5a7c91-bf0f-4afc-87a8-9f06659e8b01" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityIncorporationStateCountryCode"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityIncorporationStateCountryCode_cc5a7c91-bf0f-4afc-87a8-9f06659e8b01" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityTaxIdentificationNumber_b0d1a3c0-7335-4a6b-8c2a-86ffd2af7f5a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityTaxIdentificationNumber"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityTaxIdentificationNumber_b0d1a3c0-7335-4a6b-8c2a-86ffd2af7f5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressAddressLine1_712ac3d8-af5f-40c1-8604-2f3c4bd30c76" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressAddressLine1"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityAddressAddressLine1_712ac3d8-af5f-40c1-8604-2f3c4bd30c76" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressCityOrTown_66fb44f2-1950-4ac8-b21f-5532ec4003be" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressCityOrTown"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityAddressCityOrTown_66fb44f2-1950-4ac8-b21f-5532ec4003be" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressStateOrProvince_7f8ed432-61cd-45e2-acd0-c412e78152e2" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressStateOrProvince"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityAddressStateOrProvince_7f8ed432-61cd-45e2-acd0-c412e78152e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityAddressPostalZipCode_c6b5937a-35c7-493f-87f6-f9229b31a4f3" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityAddressPostalZipCode"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityAddressPostalZipCode_c6b5937a-35c7-493f-87f6-f9229b31a4f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CityAreaCode_1a8f8423-63ed-49c1-b42b-00cbae2a55b5" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CityAreaCode"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_CityAreaCode_1a8f8423-63ed-49c1-b42b-00cbae2a55b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LocalPhoneNumber_2dbd4547-8db0-4714-abe8-198a28e00c9d" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LocalPhoneNumber"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_LocalPhoneNumber_2dbd4547-8db0-4714-abe8-198a28e00c9d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_Security12bTitle_bedc6ec3-d540-4ae5-adf0-b10ce2b8d0d6" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_Security12bTitle"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_Security12bTitle_bedc6ec3-d540-4ae5-adf0-b10ce2b8d0d6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_TradingSymbol_e7bb1cbe-83af-4737-87c1-16611a5c813f" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_TradingSymbol"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_TradingSymbol_e7bb1cbe-83af-4737-87c1-16611a5c813f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_SecurityExchangeName_dab7f628-00a1-4fa1-bba8-09304d952e44" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_SecurityExchangeName"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_SecurityExchangeName_dab7f628-00a1-4fa1-bba8-09304d952e44" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCurrentReportingStatus_7f485a49-12be-4a26-b551-2fb27043a582" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCurrentReportingStatus"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityCurrentReportingStatus_7f485a49-12be-4a26-b551-2fb27043a582" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityInteractiveDataCurrent_9f99648f-8ae9-4722-b10c-d0284e42cf1a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityInteractiveDataCurrent"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityInteractiveDataCurrent_9f99648f-8ae9-4722-b10c-d0284e42cf1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityFilerCategory_cd149e83-452a-4ad2-901e-9faa3a66b6b0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityFilerCategory"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityFilerCategory_cd149e83-452a-4ad2-901e-9faa3a66b6b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntitySmallBusiness_2daaffb2-3247-46bf-8133-5762b21722f7" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntitySmallBusiness"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntitySmallBusiness_2daaffb2-3247-46bf-8133-5762b21722f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityEmergingGrowthCompany_599c6c2f-2a72-4c0a-b6f0-e4db6b39cb56" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityEmergingGrowthCompany"/>
    <link:presentationArc order="22" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityEmergingGrowthCompany_599c6c2f-2a72-4c0a-b6f0-e4db6b39cb56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityExTransitionPeriod_01cb9cdf-4c5b-4b3e-8c20-71fc3a69293b" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityExTransitionPeriod"/>
    <link:presentationArc order="23" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityExTransitionPeriod_01cb9cdf-4c5b-4b3e-8c20-71fc3a69293b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityShellCompany_4280d59d-224c-422a-87f0-15fae3bc16b0" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityShellCompany"/>
    <link:presentationArc order="24" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityShellCompany_4280d59d-224c-422a-87f0-15fae3bc16b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCommonStockSharesOutstanding_46b84fc4-327d-4b0d-9d4a-aad10ac44323" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCommonStockSharesOutstanding"/>
    <link:presentationArc order="25" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityCommonStockSharesOutstanding_46b84fc4-327d-4b0d-9d4a-aad10ac44323" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityCentralIndexKey_ebccc5ef-0c61-4594-81cb-2b693528b29a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityCentralIndexKey"/>
    <link:presentationArc order="26" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_EntityCentralIndexKey_ebccc5ef-0c61-4594-81cb-2b693528b29a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_CurrentFiscalYearEndDate_4fc79993-de53-4315-abf1-8bdf7f03703e" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_CurrentFiscalYearEndDate"/>
    <link:presentationArc order="27" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_CurrentFiscalYearEndDate_4fc79993-de53-4315-abf1-8bdf7f03703e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalYearFocus_3dba45a3-9563-4345-ba9b-6d7532400279" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalYearFocus"/>
    <link:presentationArc order="28" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentFiscalYearFocus_3dba45a3-9563-4345-ba9b-6d7532400279" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_DocumentFiscalPeriodFocus_fe6ec286-f575-4bfe-a5a1-312020aebd1a" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_DocumentFiscalPeriodFocus"/>
    <link:presentationArc order="29" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_DocumentFiscalPeriodFocus_fe6ec286-f575-4bfe-a5a1-312020aebd1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_AmendmentFlag_f54781d7-5b8b-409e-9ace-fef64277f0bc" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_AmendmentFlag"/>
    <link:presentationArc order="30" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_DocumentInformationLineItems_edd5c065-9c3c-42e8-9c8c-73985a870e06" xlink:to="loc_dei_AmendmentFlag_f54781d7-5b8b-409e-9ace-fef64277f0bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheets" xlink:type="simple" xlink:href="huma-20220630.xsd#CondensedConsolidatedBalanceSheets"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheets" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_b65ab3b5-74c6-4a57-b122-dd770e3aa840" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_b65ab3b5-74c6-4a57-b122-dd770e3aa840" xlink:to="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:to="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_41de0565-83fb-4380-9d40-ba719f4cd9ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:to="loc_us-gaap_CashAndCashEquivalentsAtCarryingValue_41de0565-83fb-4380-9d40-ba719f4cd9ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestments_330070b4-d795-48e1-bbf8-1338b012b199" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:to="loc_us-gaap_ShortTermInvestments_330070b4-d795-48e1-bbf8-1338b012b199" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableNetCurrent_1c946550-64c5-4a1d-895f-b70fbcaa9e73" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableNetCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:to="loc_us-gaap_AccountsReceivableNetCurrent_1c946550-64c5-4a1d-895f-b70fbcaa9e73" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a1e3d4bc-bf62-4a2c-a069-3b8bc1fd60ce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrepaidExpenseAndOtherAssetsCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:to="loc_us-gaap_PrepaidExpenseAndOtherAssetsCurrent_a1e3d4bc-bf62-4a2c-a069-3b8bc1fd60ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsCurrent_b55274bf-2fa5-49d4-a3f1-a75972bb5731" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsCurrentAbstract_13c584cd-22a8-4949-8a40-c0e7b1cd3794" xlink:to="loc_us-gaap_AssetsCurrent_b55274bf-2fa5-49d4-a3f1-a75972bb5731" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAsset_11c83e56-0950-40f9-8dbd-2382ed6649df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAsset"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAsset_11c83e56-0950-40f9-8dbd-2382ed6649df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAsset_67e608cf-177d-4797-84db-7575ce52ec53" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAsset"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAsset_67e608cf-177d-4797-84db-7575ce52ec53" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_b7d0dfb2-144b-4099-bb5b-5c53a5e7bc41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_b7d0dfb2-144b-4099-bb5b-5c53a5e7bc41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Assets_c8df38be-f9bb-499e-9769-b6b5f5ef9b7d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Assets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsAbstract_6ed8eef1-a3b0-4a1c-b35e-c9e14f6b4b81" xlink:to="loc_us-gaap_Assets_c8df38be-f9bb-499e-9769-b6b5f5ef9b7d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquityAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_b65ab3b5-74c6-4a57-b122-dd770e3aa840" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrentAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsPayableCurrent_8049d5c8-7b01-44fb-8737-cb1b05f43c0b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsPayableCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_AccountsPayableCurrent_8049d5c8-7b01-44fb-8737-cb1b05f43c0b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_62173b8e-d991-49e8-a192-956b156e0365" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_62173b8e-d991-49e8-a192-956b156e0365" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityCurrent_220caf59-a496-4e90-a8ed-a6ccfb268157" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_FinanceLeaseLiabilityCurrent_220caf59-a496-4e90-a8ed-a6ccfb268157" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedPayrollTaxesCurrent_83965883-f1aa-49ba-8add-d31cf2c7b2ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedPayrollTaxesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_AccruedPayrollTaxesCurrent_83965883-f1aa-49ba-8add-d31cf2c7b2ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityCurrent_92f91c1c-1c8a-4e18-af57-2b9d93cb83ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_OperatingLeaseLiabilityCurrent_92f91c1c-1c8a-4e18-af57-2b9d93cb83ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesCurrent_022179e9-ecbf-48f5-9510-bad5a8e18666" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesCurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesCurrentAbstract_cb24c62c-8f9c-40d8-9d98-63ea03628148" xlink:to="loc_us-gaap_LiabilitiesCurrent_022179e9-ecbf-48f5-9510-bad5a8e18666" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_4cbeee5b-0421-44b7-9a89-6a866fd51a47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_4cbeee5b-0421-44b7-9a89-6a866fd51a47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SecuredLongTermDebt_df2eda61-387b-4e3f-9246-0992bad765c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SecuredLongTermDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_SecuredLongTermDebt_df2eda61-387b-4e3f-9246-0992bad765c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_0bea0996-d191-410a-a78e-bd1cbdcc6163" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_FinanceLeaseLiabilityNoncurrent_0bea0996-d191-410a-a78e-bd1cbdcc6163" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_1cb0fc82-3e55-442d-a43d-635ca0019407" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseLiabilityNoncurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_OperatingLeaseLiabilityNoncurrent_1cb0fc82-3e55-442d-a43d-635ca0019407" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_cef69df1-57a8-4485-8f81-fbb106e44461" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_cef69df1-57a8-4485-8f81-fbb106e44461" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Liabilities_f4e43335-889c-47aa-a9a0-23a62a3bc0ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Liabilities"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_Liabilities_f4e43335-889c-47aa-a9a0-23a62a3bc0ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingencies_79de63be-01f9-4fce-9329-7369d90f5410" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingencies"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_CommitmentsAndContingencies_79de63be-01f9-4fce-9329-7369d90f5410" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityAbstract"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockValue_05f62cf5-1f4e-4aa1-8f34-4600ad3eec67" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:to="loc_us-gaap_PreferredStockValue_05f62cf5-1f4e-4aa1-8f34-4600ad3eec67" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockValue_81a57a3b-75fe-4d4e-a7b8-7a876a086553" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockValue"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:to="loc_us-gaap_CommonStockValue_81a57a3b-75fe-4d4e-a7b8-7a876a086553" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapital_3797f33a-3078-41af-bdd5-764380191d9f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:to="loc_us-gaap_AdditionalPaidInCapital_3797f33a-3078-41af-bdd5-764380191d9f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_fc5d20d6-3377-44d9-977d-c32dc01253eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_fc5d20d6-3377-44d9-977d-c32dc01253eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_125aca06-a420-4995-a076-0cb154aebf57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityAbstract_98fb8c43-4f34-4d1f-b64e-745c6249520f" xlink:to="loc_us-gaap_StockholdersEquity_125aca06-a420-4995-a076-0cb154aebf57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LiabilitiesAndStockholdersEquity_9686146e-286e-4e2a-b682-aa2f685b1e5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LiabilitiesAndStockholdersEquity"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LiabilitiesAndStockholdersEquityAbstract_7dda017d-c895-4fcb-bc61-9dbd46453075" xlink:to="loc_us-gaap_LiabilitiesAndStockholdersEquity_9686146e-286e-4e2a-b682-aa2f685b1e5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="simple" xlink:href="huma-20220630.xsd#CondensedConsolidatedBalanceSheetsParenthetical"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedBalanceSheetsParenthetical" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfFinancialPositionAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_e32c81fb-8ee3-4ab3-8572-e938cdd6bb77" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_e32c81fb-8ee3-4ab3-8572-e938cdd6bb77" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_6ed92199-c2ec-4f48-892a-3d864b9b4eaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_6ed92199-c2ec-4f48-892a-3d864b9b4eaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesIssued_389bd71a-5c4d-4acb-b2e8-3dc75fd628b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesIssued"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_PreferredStockSharesIssued_389bd71a-5c4d-4acb-b2e8-3dc75fd628b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_00ca8aa0-8ed9-49f8-9e1c-b475e39e128d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_00ca8aa0-8ed9-49f8-9e1c-b475e39e128d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_fae78ce0-f3de-477a-a36c-aa6ef9f928a8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_fae78ce0-f3de-477a-a36c-aa6ef9f928a8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_5cb04144-a84e-44ad-9f85-4b240b641b2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_5cb04144-a84e-44ad-9f85-4b240b641b2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_1acce124-f803-465a-8e3d-857e1c5ed7f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_CommonStockSharesIssued_1acce124-f803-465a-8e3d-857e1c5ed7f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_452855fc-7edd-4211-a08c-4634ed68c027" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfFinancialPositionAbstract_97ec3f25-0f62-4f16-9c7a-73cdd6c7d964" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_452855fc-7edd-4211-a08c-4634ed68c027" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="simple" xlink:href="huma-20220630.xsd#CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedStatementsofOperationsandComprehensiveIncomeLoss" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RevenueNotFromContractWithCustomer_0dccd566-d279-48e5-a75d-9d371fe0aab8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RevenueNotFromContractWithCustomer"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_RevenueNotFromContractWithCustomer_0dccd566-d279-48e5-a75d-9d371fe0aab8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpensesAbstract_ae3f876f-6441-4bd3-822c-4fd23a6d4d48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpensesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_OperatingExpensesAbstract_ae3f876f-6441-4bd3-822c-4fd23a6d4d48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpense_35c432f1-bcb9-4078-a875-0edd455ceb47" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_ae3f876f-6441-4bd3-822c-4fd23a6d4d48" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpense_35c432f1-bcb9-4078-a875-0edd455ceb47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpense_f1acab97-8b2b-4ed5-84ed-7a0af240bff0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_ae3f876f-6441-4bd3-822c-4fd23a6d4d48" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpense_f1acab97-8b2b-4ed5-84ed-7a0af240bff0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingExpenses_04d6bc5c-4e20-4605-9d44-b5641437f3dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingExpenses"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OperatingExpensesAbstract_ae3f876f-6441-4bd3-822c-4fd23a6d4d48" xlink:to="loc_us-gaap_OperatingExpenses_04d6bc5c-4e20-4605-9d44-b5641437f3dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_2e31002d-4c93-46e4-8a59-c53161dafafd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_OperatingIncomeLoss_2e31002d-4c93-46e4-8a59-c53161dafafd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OtherNonoperatingIncomeExpenseAbstract"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentIncomeInterest_d77291db-2862-4818-9997-a09a21a14c1a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentIncomeInterest"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_InvestmentIncomeInterest_d77291db-2862-4818-9997-a09a21a14c1a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_bb8eea9f-e199-441d-8a99-6b905413c729" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_bb8eea9f-e199-441d-8a99-6b905413c729" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_746eb9e3-e076-46a7-9abd-f12125264887" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_746eb9e3-e076-46a7-9abd-f12125264887" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0f539a78-3752-4fcb-8378-67c630bdbee7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_0f539a78-3752-4fcb-8378-67c630bdbee7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpense_6ebe7f8a-47f0-4845-9bf1-606fcf9885ab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpense"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_InterestExpense_6ebe7f8a-47f0-4845-9bf1-606fcf9885ab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NonoperatingIncomeExpense_3ac8a9f0-bc53-4de8-8606-373da1ec09d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NonoperatingIncomeExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OtherNonoperatingIncomeExpenseAbstract_e56e2cdf-b1cc-4936-a436-b4d667c0d0b2" xlink:to="loc_us-gaap_NonoperatingIncomeExpense_3ac8a9f0-bc53-4de8-8606-373da1ec09d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_83ebaf2b-6fdd-425f-a972-434e515b0ce8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_NetIncomeLoss_83ebaf2b-6fdd-425f-a972-434e515b0ce8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComprehensiveIncomeNetOfTax_d1fadac2-a47a-42ad-894e-8ca9498d6cfc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComprehensiveIncomeNetOfTax"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_ComprehensiveIncomeNetOfTax_d1fadac2-a47a-42ad-894e-8ca9498d6cfc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_e9b713c6-9070-4a1d-869f-3ba6b3a09803" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_EarningsPerShareBasic_e9b713c6-9070-4a1d-869f-3ba6b3a09803" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_41e10d92-8c8e-4bda-9c3a-f9c3afddbc3d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_41e10d92-8c8e-4bda-9c3a-f9c3afddbc3d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_3e120b13-ec8f-4554-9a33-82156379da39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_EarningsPerShareDiluted_3e120b13-ec8f-4554-9a33-82156379da39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1914ee65-4b5c-4f80-aafa-e180b12d91f2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfIncomeAndComprehensiveIncomeAbstract_d7cb963b-c6de-4b5c-8bf9-29b02a0a6b26" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_1914ee65-4b5c-4f80-aafa-e180b12d91f2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedStatementsofChangesinRedeemableConvertiblePreferredStockandStockholdersEquityDeficit" xlink:type="simple" xlink:href="huma-20220630.xsd#CondensedConsolidatedStatementsofChangesinRedeemableConvertiblePreferredStockandStockholdersEquityDeficit"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedStatementsofChangesinRedeemableConvertiblePreferredStockandStockholdersEquityDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfStockholdersEquityAbstract_2b7297e0-2ffd-4aaf-a936-89f0e81f0997" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfStockholdersEquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementTable_a500a56c-5a17-4124-b30d-017074d65ad1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfStockholdersEquityAbstract_2b7297e0-2ffd-4aaf-a936-89f0e81f0997" xlink:to="loc_us-gaap_StatementTable_a500a56c-5a17-4124-b30d-017074d65ad1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_5e548508-1e18-4251-9ae5-2ecb2be5399c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_a500a56c-5a17-4124-b30d-017074d65ad1" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_5e548508-1e18-4251-9ae5-2ecb2be5399c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_6d3878df-47d9-47a2-9ced-c840d0dc44d8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_5e548508-1e18-4251-9ae5-2ecb2be5399c" xlink:to="loc_us-gaap_EquityComponentDomain_6d3878df-47d9-47a2-9ced-c840d0dc44d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_03d62123-3875-4c5f-8855-4b445fe9ab0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6d3878df-47d9-47a2-9ced-c840d0dc44d8" xlink:to="loc_us-gaap_CommonStockMember_03d62123-3875-4c5f-8855-4b445fe9ab0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdditionalPaidInCapitalMember_92643e8b-0593-40d7-8903-533cfa008feb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdditionalPaidInCapitalMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6d3878df-47d9-47a2-9ced-c840d0dc44d8" xlink:to="loc_us-gaap_AdditionalPaidInCapitalMember_92643e8b-0593-40d7-8903-533cfa008feb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsMember_fe5a146d-3507-4897-bbc2-aca249a3674c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_6d3878df-47d9-47a2-9ced-c840d0dc44d8" xlink:to="loc_us-gaap_RetainedEarningsMember_fe5a146d-3507-4897-bbc2-aca249a3674c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementLineItems_bdabdeff-f7d6-474d-847d-376c9318e7fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementTable_a500a56c-5a17-4124-b30d-017074d65ad1" xlink:to="loc_us-gaap_StatementLineItems_bdabdeff-f7d6-474d-847d-376c9318e7fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInTemporaryEquityRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_bdabdeff-f7d6-474d-847d-376c9318e7fd" xlink:to="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_a58cae0e-d1c9-447e-983a-2841c8d0aaf4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_a58cae0e-d1c9-447e-983a-2841c8d0aaf4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_bd14137d-231a-4307-9878-95d217c11073" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_bd14137d-231a-4307-9878-95d217c11073" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquitySharesOutstanding_dd61797e-8a14-4300-821b-dac62bc2575f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquitySharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:to="loc_us-gaap_TemporaryEquitySharesOutstanding_dd61797e-8a14-4300-821b-dac62bc2575f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_716d5b18-fbc4-4190-a6b3-329d2f6d21b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TemporaryEquityCarryingAmountAttributableToParent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInTemporaryEquityRollForward_0d4b9107-580a-4f16-8307-778f373ce142" xlink:to="loc_us-gaap_TemporaryEquityCarryingAmountAttributableToParent_716d5b18-fbc4-4190-a6b3-329d2f6d21b6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInStockholdersEquityRollForward"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementLineItems_bdabdeff-f7d6-474d-847d-376c9318e7fd" xlink:to="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_eef169d4-a313-489a-9660-514fc1e5de92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_eef169d4-a313-489a-9660-514fc1e5de92" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_0327dfa9-e7d1-40ac-9cad-6af6399f1a2b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_StockholdersEquity_0327dfa9-e7d1-40ac-9cad-6af6399f1a2b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_34fa0779-859e-49c5-b048-ab70ce5ff480" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_34fa0779-859e-49c5-b048-ab70ce5ff480" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_5e956606-cb28-47f2-84e4-919dbe65fa51" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_StockIssuedDuringPeriodValueStockOptionsExercised_5e956606-cb28-47f2-84e4-919dbe65fa51" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_35075694-24dd-4e89-b6fd-e33f0fca855f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalSharebasedCompensationRequisiteServicePeriodRecognitionValue_35075694-24dd-4e89-b6fd-e33f0fca855f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AdjustmentsToAdditionalPaidInCapitalWarrantIssuedInConjunctionWithDebt_c3e6c902-eae0-47ac-a867-a818577c8c6c" xlink:href="huma-20220630.xsd#huma_AdjustmentsToAdditionalPaidInCapitalWarrantIssuedInConjunctionWithDebt"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_huma_AdjustmentsToAdditionalPaidInCapitalWarrantIssuedInConjunctionWithDebt_c3e6c902-eae0-47ac-a867-a818577c8c6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_2dd539ce-56c2-4383-94bb-4cf23ab1a681" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_NetIncomeLoss_2dd539ce-56c2-4383-94bb-4cf23ab1a681" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_17b18d4e-0990-4d68-965e-b73f8158161c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_17b18d4e-0990-4d68-965e-b73f8158161c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquity_cd8754d2-8744-4d79-9de9-5b3570750b16" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquity"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInStockholdersEquityRollForward_6732d728-ecf7-46cb-a88e-a0e54163e630" xlink:to="loc_us-gaap_StockholdersEquity_cd8754d2-8744-4d79-9de9-5b3570750b16" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="simple" xlink:href="huma-20220630.xsd#CondensedConsolidatedStatementsofCashFlows"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CondensedConsolidatedStatementsofCashFlows" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementOfCashFlowsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_007e4a93-6829-44cd-8783-bd3318cfbfaa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_007e4a93-6829-44cd-8783-bd3318cfbfaa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_eb2f97e4-0317-4512-9534-1b289667dd0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_007e4a93-6829-44cd-8783-bd3318cfbfaa" xlink:to="loc_us-gaap_NetIncomeLoss_eb2f97e4-0317-4512-9534-1b289667dd0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/netLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_007e4a93-6829-44cd-8783-bd3318cfbfaa" xlink:to="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_b2ab4dbb-4e35-413f-a96c-f4fe840f409c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_Depreciation_b2ab4dbb-4e35-413f-a96c-f4fe840f409c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensation_91bbdfc2-7559-4b95-bb7d-75a300568017" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensation"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_ShareBasedCompensation_91bbdfc2-7559-4b95-bb7d-75a300568017" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b23418b6-94a1-4503-a0b0-1871248612d1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_b23418b6-94a1-4503-a0b0-1871248612d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_57f82085-748b-41f6-8419-297fdd93081f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_57f82085-748b-41f6-8419-297fdd93081f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_7aaafe7b-f632-4094-941a-ca123ad06622" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeaseRightOfUseAssetAmortization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_FinanceLeaseRightOfUseAssetAmortization_7aaafe7b-f632-4094-941a-ca123ad06622" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_0106cb49-a922-423b-8bcd-0afa0550af4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_OperatingLeaseRightOfUseAssetAmortizationExpense_0106cb49-a922-423b-8bcd-0afa0550af4a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfDebtDiscountPremium_5a20c360-d930-4318-aebe-831ea96fece7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfDebtDiscountPremium"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_AmortizationOfDebtDiscountPremium_5a20c360-d930-4318-aebe-831ea96fece7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestExpenseDebtExcludingAmortization_8786a069-4d10-4013-bd91-a54618c3c10e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestExpenseDebtExcludingAmortization"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_InterestExpenseDebtExcludingAmortization_8786a069-4d10-4013-bd91-a54618c3c10e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ff96cd80-d2ff-472b-a59b-156ebb5e0311" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ff96cd80-d2ff-472b-a59b-156ebb5e0311" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingCapitalAbstract"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AdjustmentsToReconcileNetIncomeLossToCashProvidedByUsedInOperatingActivitiesAbstract_a8603753-8486-4c21-99c1-8643e129481f" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_680a4007-138c-412e-9253-318933dd3df9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsReceivable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsReceivable_680a4007-138c-412e-9253-318933dd3df9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_ebd54789-0c6a-4efa-92dc-505fa8f1c95a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInPrepaidExpense"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:to="loc_us-gaap_IncreaseDecreaseInPrepaidExpense_ebd54789-0c6a-4efa-92dc-505fa8f1c95a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccountsPayable_0f2f6a3d-d475-496e-b179-56624cbabccc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccountsPayable"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:to="loc_us-gaap_IncreaseDecreaseInAccountsPayable_0f2f6a3d-d475-496e-b179-56624cbabccc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_ad599992-ad89-4003-9edc-7f4b0dc3da6e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInAccruedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:to="loc_us-gaap_IncreaseDecreaseInAccruedLiabilities_ad599992-ad89-4003-9edc-7f4b0dc3da6e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_7306e406-4fae-431e-8965-5cdfcc100b3c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncreaseDecreaseInOperatingLeaseLiability"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncreaseDecreaseInOperatingCapitalAbstract_9a8fee77-23c1-4cc3-9818-9b46c622d046" xlink:to="loc_us-gaap_IncreaseDecreaseInOperatingLeaseLiability_7306e406-4fae-431e-8965-5cdfcc100b3c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ff9039f6-7aec-4125-aa99-739742bf5118" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInOperatingActivitiesAbstract_007e4a93-6829-44cd-8783-bd3318cfbfaa" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_ff9039f6-7aec-4125-aa99-739742bf5118" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquireShortTermInvestments_c6dccc56-0bda-4734-a865-541ae1bd665f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquireShortTermInvestments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:to="loc_us-gaap_PaymentsToAcquireShortTermInvestments_c6dccc56-0bda-4734-a865-541ae1bd665f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_749c3c1b-80de-4cda-9b29-a7daed89efda" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:to="loc_us-gaap_ProceedsFromMaturitiesPrepaymentsAndCallsOfShorttermInvestments_749c3c1b-80de-4cda-9b29-a7daed89efda" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_84cb744d-2a2c-4fd8-8ca7-8a6f54eb51ca" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsToAcquirePropertyPlantAndEquipment"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:to="loc_us-gaap_PaymentsToAcquirePropertyPlantAndEquipment_84cb744d-2a2c-4fd8-8ca7-8a6f54eb51ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_33471faf-184d-4ae5-86b1-523b1af8d268" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInInvestingActivities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInInvestingActivitiesAbstract_6818dbca-76a7-4f69-93db-a58bfb76396a" xlink:to="loc_us-gaap_NetCashProvidedByUsedInInvestingActivities_33471faf-184d-4ae5-86b1-523b1af8d268" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromStockOptionsExercised_3f869533-f802-4f13-8449-d89eb1c822c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromStockOptionsExercised"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:to="loc_us-gaap_ProceedsFromStockOptionsExercised_3f869533-f802-4f13-8449-d89eb1c822c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinanceLeasePrincipalPayments_2f847bb4-83f4-4fd4-aaee-62ddc9becfcd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinanceLeasePrincipalPayments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:to="loc_us-gaap_FinanceLeasePrincipalPayments_2f847bb4-83f4-4fd4-aaee-62ddc9becfcd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromBankDebt_0d9600ad-419a-4def-bc26-8aecb7014cfb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromBankDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:to="loc_us-gaap_ProceedsFromBankDebt_0d9600ad-419a-4def-bc26-8aecb7014cfb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PaymentsOfStockIssuanceCosts_f01742ca-891d-4bea-99c7-ce2f90d98ff6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PaymentsOfStockIssuanceCosts"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:to="loc_us-gaap_PaymentsOfStockIssuanceCosts_f01742ca-891d-4bea-99c7-ce2f90d98ff6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_cf1cb917-97e8-4092-9a38-226cb04486fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInFinancingActivities"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetCashProvidedByUsedInFinancingActivitiesAbstract_d9bc773d-39ce-473a-98d5-bd0e22de2dce" xlink:to="loc_us-gaap_NetCashProvidedByUsedInFinancingActivities_cf1cb917-97e8-4092-9a38-226cb04486fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ba30e00c-929e-41e3-8aaf-818f61b5bae3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalentsPeriodIncreaseDecreaseIncludingExchangeRateEffect_ba30e00c-929e-41e3-8aaf-818f61b5bae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ed63d1f9-eb99-48a4-87bf-dbeb582cec0d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_ed63d1f9-eb99-48a4-87bf-dbeb582cec0d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4392f42c-e3cf-470a-b987-6c59cd810171" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_CashCashEquivalentsRestrictedCashAndRestrictedCashEquivalents_4392f42c-e3cf-470a-b987-6c59cd810171" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SupplementalCashFlowInformationAbstract_0a07ee48-6972-4804-94ed-c01dafd44e87" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SupplementalCashFlowInformationAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_SupplementalCashFlowInformationAbstract_0a07ee48-6972-4804-94ed-c01dafd44e87" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InterestPaidNet_78b29761-a774-4151-bdf4-ff65c5d9e469" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InterestPaidNet"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SupplementalCashFlowInformationAbstract_0a07ee48-6972-4804-94ed-c01dafd44e87" xlink:to="loc_us-gaap_InterestPaidNet_78b29761-a774-4151-bdf4-ff65c5d9e469" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_76e0c585-4cd1-4ea6-a36e-90013ba7cb54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NoncashInvestingAndFinancingItemsAbstract"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementOfCashFlowsAbstract_356b30e7-7838-4f17-86ce-cd6c4af3602d" xlink:to="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_76e0c585-4cd1-4ea6-a36e-90013ba7cb54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_ab26ba7f-402a-4985-a52f-56bfd0bbf9f8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CapitalExpendituresIncurredButNotYetPaid"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_76e0c585-4cd1-4ea6-a36e-90013ba7cb54" xlink:to="loc_us-gaap_CapitalExpendituresIncurredButNotYetPaid_ab26ba7f-402a-4985-a52f-56bfd0bbf9f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_IssuanceOfStockWarrantsInConjunctionWithDebt_d01f1154-0afa-4154-8b25-db39edc1de97" xlink:href="huma-20220630.xsd#huma_IssuanceOfStockWarrantsInConjunctionWithDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_76e0c585-4cd1-4ea6-a36e-90013ba7cb54" xlink:to="loc_huma_IssuanceOfStockWarrantsInConjunctionWithDebt_d01f1154-0afa-4154-8b25-db39edc1de97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DeferredOfferingCostsIncurredButNotYetPaid_f2e737b1-e9a0-4c12-aba0-a0b4518be89a" xlink:href="huma-20220630.xsd#huma_DeferredOfferingCostsIncurredButNotYetPaid"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NoncashInvestingAndFinancingItemsAbstract_76e0c585-4cd1-4ea6-a36e-90013ba7cb54" xlink:to="loc_huma_DeferredOfferingCostsIncurredButNotYetPaid_f2e737b1-e9a0-4c12-aba0-a0b4518be89a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/OrganizationandDescriptionofBusiness" xlink:type="simple" xlink:href="huma-20220630.xsd#OrganizationandDescriptionofBusiness"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/OrganizationandDescriptionofBusiness" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3a06cbd0-719b-421e-ad60-46584d14e7e3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_f7134906-289a-4da0-be23-57de44f3edd6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_3a06cbd0-719b-421e-ad60-46584d14e7e3" xlink:to="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsDisclosureTextBlock_f7134906-289a-4da0-be23-57de44f3edd6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/OrganizationandDescriptionofBusinessDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#OrganizationandDescriptionofBusinessDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/OrganizationandDescriptionofBusinessDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1adc8e22-3e94-4e3d-b42d-99ac57c7119b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RetainedEarningsAccumulatedDeficit_20410e54-0262-459d-a70b-94e7aed79e26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RetainedEarningsAccumulatedDeficit"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1adc8e22-3e94-4e3d-b42d-99ac57c7119b" xlink:to="loc_us-gaap_RetainedEarningsAccumulatedDeficit_20410e54-0262-459d-a70b-94e7aed79e26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_OperatingIncomeLoss_07f31e27-9632-499a-8930-c1862d8cbfbb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_OperatingIncomeLoss"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1adc8e22-3e94-4e3d-b42d-99ac57c7119b" xlink:to="loc_us-gaap_OperatingIncomeLoss_07f31e27-9632-499a-8930-c1862d8cbfbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8e46bd81-c54e-4040-84cd-e043f248c92b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetCashProvidedByUsedInOperatingActivities"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1adc8e22-3e94-4e3d-b42d-99ac57c7119b" xlink:to="loc_us-gaap_NetCashProvidedByUsedInOperatingActivities_8e46bd81-c54e-4040-84cd-e043f248c92b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_2444c1ca-3a7f-4aac-9f80-1df07c6d23e9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashCashEquivalentsAndShortTermInvestments"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_OrganizationConsolidationAndPresentationOfFinancialStatementsAbstract_1adc8e22-3e94-4e3d-b42d-99ac57c7119b" xlink:to="loc_us-gaap_CashCashEquivalentsAndShortTermInvestments_2444c1ca-3a7f-4aac-9f80-1df07c6d23e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPolicies" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPolicies"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_03e25847-1846-4f53-8c84-81434fc3f2f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SignificantAccountingPoliciesTextBlock_2ff0bb17-4e33-42e1-8f1b-80dc00707ab1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SignificantAccountingPoliciesTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_03e25847-1846-4f53-8c84-81434fc3f2f3" xlink:to="loc_us-gaap_SignificantAccountingPoliciesTextBlock_2ff0bb17-4e33-42e1-8f1b-80dc00707ab1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesPolicies"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesPolicies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_c67fdae3-b52a-439d-bf67-0f9e77506a72" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BasisOfAccountingPolicyPolicyTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_BasisOfAccountingPolicyPolicyTextBlock_c67fdae3-b52a-439d-bf67-0f9e77506a72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_UseOfEstimates_cc0a9b17-efd0-48f8-b9cc-f4c176a25d23" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_UseOfEstimates"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_UseOfEstimates_cc0a9b17-efd0-48f8-b9cc-f4c176a25d23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_0d129018-174a-4c22-b612-f1762b1ac3c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SegmentReportingPolicyPolicyTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_SegmentReportingPolicyPolicyTextBlock_0d129018-174a-4c22-b612-f1762b1ac3c0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskCreditRisk_6bbc0fcf-0c29-44f2-95de-897ab0f7dab3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskCreditRisk"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_ConcentrationRiskCreditRisk_6bbc0fcf-0c29-44f2-95de-897ab0f7dab3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerSharePolicyTextBlock_ccab2bcd-d36d-4b71-aa05-61eb0c91d2dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerSharePolicyTextBlock"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_EarningsPerSharePolicyTextBlock_ccab2bcd-d36d-4b71-aa05-61eb0c91d2dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_28b83435-9f53-4566-ace4-fcf20ef5496e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_NewAccountingPronouncementsPolicyPolicyTextBlock_28b83435-9f53-4566-ace4-fcf20ef5496e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueOfFinancialInstrumentsPolicy_07e8654b-f95c-4e49-a8ce-032994945a7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueOfFinancialInstrumentsPolicy"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_FairValueOfFinancialInstrumentsPolicy_07e8654b-f95c-4e49-a8ce-032994945a7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_7a58ea66-1c20-4f88-a225-9df30bc02879" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_ShareBasedCompensationOptionAndIncentivePlansPolicy_7a58ea66-1c20-4f88-a225-9df30bc02879" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_WarrantsAndRightsOutstandingPolicyPolicyTextBlock_698a8f25-0e09-4707-9a78-71fab358fbbb" xlink:href="huma-20220630.xsd#huma_WarrantsAndRightsOutstandingPolicyPolicyTextBlock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_huma_WarrantsAndRightsOutstandingPolicyPolicyTextBlock_698a8f25-0e09-4707-9a78-71fab358fbbb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationsPolicy_89cd77e3-ffa3-4926-9799-edada4319891" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationsPolicy"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_10305f00-6692-4469-99f1-36f4d77e1fc2" xlink:to="loc_us-gaap_BusinessCombinationsPolicy_89cd77e3-ffa3-4926-9799-edada4319891" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_11a7ed67-072e-4f39-b308-fa37cdcd6b75" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_4b97bb17-c96c-480b-a61d-dc924f0fca95" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_11a7ed67-072e-4f39-b308-fa37cdcd6b75" xlink:to="loc_us-gaap_ScheduleOfEarningsPerShareBasicAndDilutedTableTextBlock_4b97bb17-c96c-480b-a61d-dc924f0fca95" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_34be2a2b-4047-4da7-b1c1-ade0bb6aa817" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_11a7ed67-072e-4f39-b308-fa37cdcd6b75" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTextBlock_34be2a2b-4047-4da7-b1c1-ade0bb6aa817" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesSegmentsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesSegmentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_b1f184d8-89e9-4119-946a-568a62f21c9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfReportableSegments_6dec5316-3b3d-4eda-b637-6a995c559d2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfReportableSegments"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b1f184d8-89e9-4119-946a-568a62f21c9e" xlink:to="loc_us-gaap_NumberOfReportableSegments_6dec5316-3b3d-4eda-b637-6a995c559d2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NumberOfOperatingSegments_f4a6e895-95f6-4a5f-a50e-0d93a62d12ad" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NumberOfOperatingSegments"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_b1f184d8-89e9-4119-946a-568a62f21c9e" xlink:to="loc_us-gaap_NumberOfOperatingSegments_f4a6e895-95f6-4a5f-a50e-0d93a62d12ad" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesConcentrationofCreditRiskDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesConcentrationofCreditRiskDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesConcentrationofCreditRiskDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_8ef937a5-bddc-42ee-9784-e455eeb13f70" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_8ef937a5-bddc-42ee-9784-e455eeb13f70" xlink:to="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_222dcd53-7cee-4dd5-99d6-31cf82d8de63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_222dcd53-7cee-4dd5-99d6-31cf82d8de63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_636720cd-42a6-4978-8099-c5f44642bf30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_222dcd53-7cee-4dd5-99d6-31cf82d8de63" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_636720cd-42a6-4978-8099-c5f44642bf30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsMember_1e454fd2-2244-4258-83d3-65bd49c7feaf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_636720cd-42a6-4978-8099-c5f44642bf30" xlink:to="loc_us-gaap_CashAndCashEquivalentsMember_1e454fd2-2244-4258-83d3-65bd49c7feaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShortTermInvestmentsMember_4af28ad7-91cb-4603-ac46-ca84dffaea71" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShortTermInvestmentsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_636720cd-42a6-4978-8099-c5f44642bf30" xlink:to="loc_us-gaap_ShortTermInvestmentsMember_4af28ad7-91cb-4603-ac46-ca84dffaea71" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByTypeAxis_7517d66d-e30d-434d-a4c7-ea564bbbcd0c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:to="loc_us-gaap_ConcentrationRiskByTypeAxis_7517d66d-e30d-434d-a4c7-ea564bbbcd0c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskTypeDomain_70adfc58-e8e0-40a4-b578-ce344beb1576" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByTypeAxis_7517d66d-e30d-434d-a4c7-ea564bbbcd0c" xlink:to="loc_us-gaap_ConcentrationRiskTypeDomain_70adfc58-e8e0-40a4-b578-ce344beb1576" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GovernmentContractsConcentrationRiskMember_9614dcbd-9897-4106-9c2f-5fcd363af104" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GovernmentContractsConcentrationRiskMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_70adfc58-e8e0-40a4-b578-ce344beb1576" xlink:to="loc_us-gaap_GovernmentContractsConcentrationRiskMember_9614dcbd-9897-4106-9c2f-5fcd363af104" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CreditConcentrationRiskMember_fa9e5994-0821-4603-af12-6094e2b14e28" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CreditConcentrationRiskMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTypeDomain_70adfc58-e8e0-40a4-b578-ce344beb1576" xlink:to="loc_us-gaap_CreditConcentrationRiskMember_fa9e5994-0821-4603-af12-6094e2b14e28" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_c7c32e02-e57c-4988-84c4-076c3698fd3b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskByBenchmarkAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:to="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_c7c32e02-e57c-4988-84c4-076c3698fd3b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b2da1fe4-6bba-4a42-aacf-5efb68414fb4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskBenchmarkDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskByBenchmarkAxis_c7c32e02-e57c-4988-84c4-076c3698fd3b" xlink:to="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b2da1fe4-6bba-4a42-aacf-5efb68414fb4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SalesRevenueNetMember_221cf80f-d08d-4f92-9b53-e7d7c9987954" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SalesRevenueNetMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b2da1fe4-6bba-4a42-aacf-5efb68414fb4" xlink:to="loc_us-gaap_SalesRevenueNetMember_221cf80f-d08d-4f92-9b53-e7d7c9987954" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountsReceivableMember_1899b83a-ad83-4b33-aa00-1bbfc22e5b7e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountsReceivableMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskBenchmarkDomain_b2da1fe4-6bba-4a42-aacf-5efb68414fb4" xlink:to="loc_us-gaap_AccountsReceivableMember_1899b83a-ad83-4b33-aa00-1bbfc22e5b7e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_da501ae2-2ccf-458f-8786-cdca07ce0147" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:to="loc_srt_ProductOrServiceAxis_da501ae2-2ccf-458f-8786-cdca07ce0147" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_2e1406d4-14ff-419e-8672-a1d96bcc2769" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_da501ae2-2ccf-458f-8786-cdca07ce0147" xlink:to="loc_srt_ProductsAndServicesDomain_2e1406d4-14ff-419e-8672-a1d96bcc2769" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_RevenueFromGrantsMember_73ea2733-2789-413f-ade3-b2b260f5b9a7" xlink:href="huma-20220630.xsd#huma_RevenueFromGrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_2e1406d4-14ff-419e-8672-a1d96bcc2769" xlink:to="loc_huma_RevenueFromGrantsMember_73ea2733-2789-413f-ade3-b2b260f5b9a7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskLineItems_620c2191-19a0-4ab9-946d-89e1e726e7df" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskTable_bb146a5d-99bd-4613-bf3d-03984fbc9890" xlink:to="loc_us-gaap_ConcentrationRiskLineItems_620c2191-19a0-4ab9-946d-89e1e726e7df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositAtCarryingValue_81b6365a-6797-4113-9c94-d5e9d3fd5ca4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositAtCarryingValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_620c2191-19a0-4ab9-946d-89e1e726e7df" xlink:to="loc_us-gaap_CertificatesOfDepositAtCarryingValue_81b6365a-6797-4113-9c94-d5e9d3fd5ca4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConcentrationRiskPercentage1_6041f93e-7053-4a20-b9ee-fe4843db8f3a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConcentrationRiskPercentage1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ConcentrationRiskLineItems_620c2191-19a0-4ab9-946d-89e1e726e7df" xlink:to="loc_us-gaap_ConcentrationRiskPercentage1_6041f93e-7053-4a20-b9ee-fe4843db8f3a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesScheduleofEarningsLossPerShareDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesScheduleofEarningsLossPerShareDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesScheduleofEarningsLossPerShareDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_ec9b8e20-3c49-47da-b5b3-9c0d670cb6a6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLossAbstract_377e04d4-162a-4433-b142-b885a7bebfd3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLossAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ec9b8e20-3c49-47da-b5b3-9c0d670cb6a6" xlink:to="loc_us-gaap_NetIncomeLossAbstract_377e04d4-162a-4433-b142-b885a7bebfd3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_NetIncomeLoss_58582159-1ec2-4f0f-a294-a2286ec9d291" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_NetIncomeLoss"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_NetIncomeLossAbstract_377e04d4-162a-4433-b142-b885a7bebfd3" xlink:to="loc_us-gaap_NetIncomeLoss_58582159-1ec2-4f0f-a294-a2286ec9d291" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_59a9d1d6-c4dc-4065-8c1f-259393217442" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ec9b8e20-3c49-47da-b5b3-9c0d670cb6a6" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_59a9d1d6-c4dc-4065-8c1f-259393217442" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7f2f89bc-2462-4f4c-8d3e-c930006bd170" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfSharesOutstandingBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_59a9d1d6-c4dc-4065-8c1f-259393217442" xlink:to="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingBasic_7f2f89bc-2462-4f4c-8d3e-c930006bd170" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_37432b13-c6a0-4f29-a297-f5973190849f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_59a9d1d6-c4dc-4065-8c1f-259393217442" xlink:to="loc_us-gaap_IncrementalCommonSharesAttributableToShareBasedPaymentArrangements_37432b13-c6a0-4f29-a297-f5973190849f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9c1c4004-c5d5-4129-ba64-d908b9cfee0a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_WeightedAverageNumberOfSharesOutstandingAbstract_59a9d1d6-c4dc-4065-8c1f-259393217442" xlink:to="loc_us-gaap_WeightedAverageNumberOfDilutedSharesOutstanding_9c1c4004-c5d5-4129-ba64-d908b9cfee0a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_EarningsPerShareBasicAndDilutedEPSAbstract_434c63f9-693a-4d25-97e6-90fb67b4acd0" xlink:href="huma-20220630.xsd#huma_EarningsPerShareBasicAndDilutedEPSAbstract"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_ec9b8e20-3c49-47da-b5b3-9c0d670cb6a6" xlink:to="loc_huma_EarningsPerShareBasicAndDilutedEPSAbstract_434c63f9-693a-4d25-97e6-90fb67b4acd0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareBasic_dd370bfd-d99d-4138-a49a-13bec61bd8aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareBasic"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_EarningsPerShareBasicAndDilutedEPSAbstract_434c63f9-693a-4d25-97e6-90fb67b4acd0" xlink:to="loc_us-gaap_EarningsPerShareBasic_dd370bfd-d99d-4138-a49a-13bec61bd8aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EarningsPerShareDiluted_bb034558-f1db-4706-b391-7e6d3ec5a590" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EarningsPerShareDiluted"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_EarningsPerShareBasicAndDilutedEPSAbstract_434c63f9-693a-4d25-97e6-90fb67b4acd0" xlink:to="loc_us-gaap_EarningsPerShareDiluted_bb034558-f1db-4706-b391-7e6d3ec5a590" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesAntidilutiveSecuritiesExcludedFromComputationDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#SummaryofSignificantAccountingPoliciesAntidilutiveSecuritiesExcludedFromComputationDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/SummaryofSignificantAccountingPoliciesAntidilutiveSecuritiesExcludedFromComputationDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccountingPoliciesAbstract_c777ae72-8361-4d43-8537-dcfaeb0f2400" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccountingPoliciesAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_fc7bf8da-681b-453b-86f9-5639921b09d4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccountingPoliciesAbstract_c777ae72-8361-4d43-8537-dcfaeb0f2400" xlink:to="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_fc7bf8da-681b-453b-86f9-5639921b09d4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1912e13e-8f15-44bf-a722-abc3e99c9baf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_fc7bf8da-681b-453b-86f9-5639921b09d4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1912e13e-8f15-44bf-a722-abc3e99c9baf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesNameDomain_dc918da7-82b8-4efe-bdbc-ad76387a0f37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareByAntidilutiveSecuritiesAxis_1912e13e-8f15-44bf-a722-abc3e99c9baf" xlink:to="loc_us-gaap_AntidilutiveSecuritiesNameDomain_dc918da7-82b8-4efe-bdbc-ad76387a0f37" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RedeemableConvertiblePreferredStockMember_f1eb3e49-41f2-4a78-9f53-48b4a615ab14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RedeemableConvertiblePreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_dc918da7-82b8-4efe-bdbc-ad76387a0f37" xlink:to="loc_us-gaap_RedeemableConvertiblePreferredStockMember_f1eb3e49-41f2-4a78-9f53-48b4a615ab14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_e429ef4f-d5ed-4248-a8aa-d3bd592832bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_dc918da7-82b8-4efe-bdbc-ad76387a0f37" xlink:to="loc_us-gaap_EmployeeStockOptionMember_e429ef4f-d5ed-4248-a8aa-d3bd592832bc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_60ad84fd-d447-4e0e-bdcf-483b731d8448" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesNameDomain_dc918da7-82b8-4efe-bdbc-ad76387a0f37" xlink:to="loc_us-gaap_WarrantMember_60ad84fd-d447-4e0e-bdcf-483b731d8448" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_6528a03a-7196-43cc-8e06-98ed6093ef05" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_fc7bf8da-681b-453b-86f9-5639921b09d4" xlink:to="loc_us-gaap_StatementClassOfStockAxis_6528a03a-7196-43cc-8e06-98ed6093ef05" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_6528a03a-7196-43cc-8e06-98ed6093ef05" xlink:to="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesAPreferredStockMember_d7f077ec-5457-4719-9325-e0ee3e6c1e59" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesAPreferredStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:to="loc_us-gaap_SeriesAPreferredStockMember_d7f077ec-5457-4719-9325-e0ee3e6c1e59" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesBPreferredStockMember_4fd0a745-57fc-4461-beac-004c51a39b81" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesBPreferredStockMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:to="loc_us-gaap_SeriesBPreferredStockMember_4fd0a745-57fc-4461-beac-004c51a39b81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesCPreferredStockMember_df726a92-e01d-4f10-8619-9c46c0042b12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesCPreferredStockMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:to="loc_us-gaap_SeriesCPreferredStockMember_df726a92-e01d-4f10-8619-9c46c0042b12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SeriesDPreferredStockMember_f6dae33e-dfb2-4982-96bd-bd5354aa3a80" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SeriesDPreferredStockMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_35c8887d-7a8c-45b6-a2bc-4cb836213215" xlink:to="loc_us-gaap_SeriesDPreferredStockMember_f6dae33e-dfb2-4982-96bd-bd5354aa3a80" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_8e02bc43-4b6d-4ba0-9cf8-2559ab2d93b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfAntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareTable_fc7bf8da-681b-453b-86f9-5639921b09d4" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_8e02bc43-4b6d-4ba0-9cf8-2559ab2d93b2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_d771b8ed-26ed-493f-9ac9-b22629508797" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_8e02bc43-4b6d-4ba0-9cf8-2559ab2d93b2" xlink:to="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareAmount_d771b8ed-26ed-493f-9ac9-b22629508797" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_9055e354-19d6-4829-ad23-97ebf3099b30" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityShares"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AntidilutiveSecuritiesExcludedFromComputationOfEarningsPerShareLineItems_8e02bc43-4b6d-4ba0-9cf8-2559ab2d93b2" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_9055e354-19d6-4829-ad23-97ebf3099b30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/ReverseRecapitalization" xlink:type="simple" xlink:href="huma-20220630.xsd#ReverseRecapitalization"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/ReverseRecapitalization" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationAbstract_ebac8ff1-8f53-4ecd-b0c1-52a377cbb29f" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationDisclosureTextBlock_41260e54-14ad-421f-8b95-e63963229123" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ReverseRecapitalizationAbstract_ebac8ff1-8f53-4ecd-b0c1-52a377cbb29f" xlink:to="loc_us-gaap_BusinessCombinationDisclosureTextBlock_41260e54-14ad-421f-8b95-e63963229123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/ReverseRecapitalizationTables" xlink:type="simple" xlink:href="huma-20220630.xsd#ReverseRecapitalizationTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/ReverseRecapitalizationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationAbstract_6b737bb3-97b4-401a-bdd7-6962d407f5a9" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScheduleOfCommonStockOutstandingImmediatelyFollowingConsummationOfMergerTableTextBlock_59a1bd6f-bce9-41c1-be69-f47fd42cd57c" xlink:href="huma-20220630.xsd#huma_ScheduleOfCommonStockOutstandingImmediatelyFollowingConsummationOfMergerTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ReverseRecapitalizationAbstract_6b737bb3-97b4-401a-bdd7-6962d407f5a9" xlink:to="loc_huma_ScheduleOfCommonStockOutstandingImmediatelyFollowingConsummationOfMergerTableTextBlock_59a1bd6f-bce9-41c1-be69-f47fd42cd57c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/ReverseRecapitalizationNarrativeDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#ReverseRecapitalizationNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/ReverseRecapitalizationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationAbstract_770a1368-0a03-4770-9365-8857526dfb74" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ReverseRecapitalizationAbstract_770a1368-0a03-4770-9365-8857526dfb74" xlink:to="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationAxis_3e666922-5cb5-4141-a135-5a387f6f0cb8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_us-gaap_BalanceSheetLocationAxis_3e666922-5cb5-4141-a135-5a387f6f0cb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BalanceSheetLocationDomain_ff345a47-8fe7-4b63-9e07-203555a0afe6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BalanceSheetLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationAxis_3e666922-5cb5-4141-a135-5a387f6f0cb8" xlink:to="loc_us-gaap_BalanceSheetLocationDomain_ff345a47-8fe7-4b63-9e07-203555a0afe6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesMember_d15f8a79-6f84-4c08-8ec8-b2e0b43095eb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BalanceSheetLocationDomain_ff345a47-8fe7-4b63-9e07-203555a0afe6" xlink:to="loc_us-gaap_AccruedLiabilitiesMember_d15f8a79-6f84-4c08-8ec8-b2e0b43095eb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTranchesAxis_ba41f82d-adbd-4389-aeeb-656e77be2611" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTranchesAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_huma_ContingentConsiderationTranchesAxis_ba41f82d-adbd-4389-aeeb-656e77be2611" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTranchesDomain_d1340ae8-4b8f-454a-b186-ff3e5c694479" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTranchesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesAxis_ba41f82d-adbd-4389-aeeb-656e77be2611" xlink:to="loc_huma_ContingentConsiderationTranchesDomain_d1340ae8-4b8f-454a-b186-ff3e5c694479" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTrancheOneMember_f4274c3b-c595-4b94-83df-7ff074be8d4b" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTrancheOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesDomain_d1340ae8-4b8f-454a-b186-ff3e5c694479" xlink:to="loc_huma_ContingentConsiderationTrancheOneMember_f4274c3b-c595-4b94-83df-7ff074be8d4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTrancheTwoMember_95fcf23e-2183-4cb4-b77d-21e2f3746bab" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTrancheTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesDomain_d1340ae8-4b8f-454a-b186-ff3e5c694479" xlink:to="loc_huma_ContingentConsiderationTrancheTwoMember_95fcf23e-2183-4cb4-b77d-21e2f3746bab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_99cdc581-802b-4280-abce-72cb3f7d5209" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_99cdc581-802b-4280-abce-72cb3f7d5209" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_cae83986-1fc2-4cab-87b3-ee1081997b48" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_99cdc581-802b-4280-abce-72cb3f7d5209" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_cae83986-1fc2-4cab-87b3-ee1081997b48" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_EarnoutSharesMember_abfc5f7b-0a45-47ea-930c-69f368bb4b70" xlink:href="huma-20220630.xsd#huma_EarnoutSharesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_cae83986-1fc2-4cab-87b3-ee1081997b48" xlink:to="loc_huma_EarnoutSharesMember_abfc5f7b-0a45-47ea-930c-69f368bb4b70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_18f9421d-bb3b-4f37-ab18-a3dd9a1a23ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_18f9421d-bb3b-4f37-ab18-a3dd9a1a23ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_392ac9e8-13c4-4ce2-8a07-b12c4a127f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_18f9421d-bb3b-4f37-ab18-a3dd9a1a23ed" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_392ac9e8-13c4-4ce2-8a07-b12c4a127f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_254f5f47-e497-4987-afaa-cd16509b0d35" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrivatePlacementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_392ac9e8-13c4-4ce2-8a07-b12c4a127f5d" xlink:to="loc_us-gaap_PrivatePlacementMember_254f5f47-e497-4987-afaa-cd16509b0d35" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_bf2a57f8-2015-484f-ae70-873c07a1ad1e" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_srt_CounterpartyNameAxis_bf2a57f8-2015-484f-ae70-873c07a1ad1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3094e03-496f-4682-a80e-648ca40e85b8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_bf2a57f8-2015-484f-ae70-873c07a1ad1e" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3094e03-496f-4682-a80e-648ca40e85b8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AHACFoundersMember_3d7ef255-7465-4764-88be-a71348811c66" xlink:href="huma-20220630.xsd#huma_AHACFoundersMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_d3094e03-496f-4682-a80e-648ca40e85b8" xlink:to="loc_huma_AHACFoundersMember_3d7ef255-7465-4764-88be-a71348811c66" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_942ddb40-af4a-4728-917b-5d707c135118" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_us-gaap_TypeOfArrangementAxis_942ddb40-af4a-4728-917b-5d707c135118" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f1bc57c-6364-4505-89d3-4e8701bbbe5e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_942ddb40-af4a-4728-917b-5d707c135118" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f1bc57c-6364-4505-89d3-4e8701bbbe5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember_9faf245c-00ae-4a93-b649-50939754184a" xlink:href="huma-20220630.xsd#huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_0f1bc57c-6364-4505-89d3-4e8701bbbe5e" xlink:to="loc_huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember_9faf245c-00ae-4a93-b649-50939754184a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetAcquisitionLineItems"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionTable_86d5304d-d476-4216-b447-b94a77ac03ec" xlink:to="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_RecapitalizationExchangeRatio_98b5894b-05eb-4de0-9813-6e6ab001d5ac" xlink:href="huma-20220630.xsd#huma_RecapitalizationExchangeRatio"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_RecapitalizationExchangeRatio_98b5894b-05eb-4de0-9813-6e6ab001d5ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_1e112549-f4c1-4efe-9747-31485b4dbff5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_1e112549-f4c1-4efe-9747-31485b4dbff5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_e83a9413-a89a-433a-8ae1-bb01b583e689" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_e83a9413-a89a-433a-8ae1-bb01b583e689" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationFounderSharesConversionRatio_8feed751-6402-432f-bcae-f7a55f7689ac" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationFounderSharesConversionRatio"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationFounderSharesConversionRatio_8feed751-6402-432f-bcae-f7a55f7689ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_29065289-6a05-44c2-890f-81abcc8bdbc9" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityShares"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_29065289-6a05-44c2-890f-81abcc8bdbc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches_2d9660c6-2452-490e-a8d3-2a28cec58178" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches_2d9660c6-2452-490e-a8d3-2a28cec58178" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche_bd404a09-6cd9-4830-be6e-570e18d1a883" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche_bd404a09-6cd9-4830-be6e-570e18d1a883" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare_63a61de3-94a5-4b36-89e9-6fbc1a15e36d" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare_63a61de3-94a5-4b36-89e9-6fbc1a15e36d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays_1f11c881-37ec-4489-a298-29e74dfcbdaf" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays_1f11c881-37ec-4489-a298-29e74dfcbdaf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod_664c41e1-fe00-4188-a042-797b11b04c0f" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod_664c41e1-fe00-4188-a042-797b11b04c0f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized_bfeba64a-6ae2-472c-bee2-232be522c12c" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized_bfeba64a-6ae2-472c-bee2-232be522c12c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_1d916077-c0e6-44c4-9899-8b78df46d80f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_SaleOfStockNumberOfSharesIssuedInTransaction_1d916077-c0e6-44c4-9899-8b78df46d80f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockPricePerShare_2360ca71-c717-4f5c-b361-e0c0818d7795" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockPricePerShare"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_SaleOfStockPricePerShare_2360ca71-c717-4f5c-b361-e0c0818d7795" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_6c9a2de5-e119-4c4d-8e3b-59c5609059f6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockConsiderationReceivedOnTransaction"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_SaleOfStockConsiderationReceivedOnTransaction_6c9a2de5-e119-4c4d-8e3b-59c5609059f6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_b5deda1c-d291-4374-bb34-15fa472d57a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_b5deda1c-d291-4374-bb34-15fa472d57a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_TransactionCostsForRaisingCapital_146a994d-804a-45ab-8f3a-1c39b51d55f7" xlink:href="huma-20220630.xsd#huma_TransactionCostsForRaisingCapital"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_TransactionCostsForRaisingCapital_146a994d-804a-45ab-8f3a-1c39b51d55f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_5507e9a4-e90e-4903-8322-916bb68bbffd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_AdjustmentsToAdditionalPaidInCapitalStockIssuedIssuanceCosts_5507e9a4-e90e-4903-8322-916bb68bbffd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProfessionalFees_f665fc13-4a78-4c63-932a-3c98c385894b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProfessionalFees"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_ProfessionalFees_f665fc13-4a78-4c63-932a-3c98c385894b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d5b2f64e-081d-461c-8fc8-ad41cd0ebce3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_d5b2f64e-081d-461c-8fc8-ad41cd0ebce3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_5ff9c8e1-7fb9-4fd6-acca-34565bb165b0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:presentationArc order="20" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_5ff9c8e1-7fb9-4fd6-acca-34565bb165b0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_UnpaidLiabilitiesAssumedInConnectionWithMerger_2ed95a6e-370d-4111-8c53-485b2a7bf9c5" xlink:href="huma-20220630.xsd#huma_UnpaidLiabilitiesAssumedInConnectionWithMerger"/>
    <link:presentationArc order="21" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetAcquisitionLineItems_59f02521-9b05-485e-bc46-3704f852c9c4" xlink:to="loc_huma_UnpaidLiabilitiesAssumedInConnectionWithMerger_2ed95a6e-370d-4111-8c53-485b2a7bf9c5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/ReverseRecapitalizationCommonStockOutstandingImmediatelyFollowingtheConsummationoftheMergerDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#ReverseRecapitalizationCommonStockOutstandingImmediatelyFollowingtheConsummationoftheMergerDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/ReverseRecapitalizationCommonStockOutstandingImmediatelyFollowingtheConsummationoftheMergerDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationAbstract_3aaaae85-651a-4419-aad5-32e35d177523" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScheduleOfReverseRecapitalizationTable_f68fa47f-7b25-4852-803d-675b5d316303" xlink:href="huma-20220630.xsd#huma_ScheduleOfReverseRecapitalizationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ReverseRecapitalizationAbstract_3aaaae85-651a-4419-aad5-32e35d177523" xlink:to="loc_huma_ScheduleOfReverseRecapitalizationTable_f68fa47f-7b25-4852-803d-675b5d316303" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_e3ee2663-5250-4867-822e-61e52012c225" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationTable_f68fa47f-7b25-4852-803d-675b5d316303" xlink:to="loc_dei_LegalEntityAxis_e3ee2663-5250-4867-822e-61e52012c225" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_d968b15b-b97f-4a62-9ef2-a03cb1101bd4" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_e3ee2663-5250-4867-822e-61e52012c225" xlink:to="loc_dei_EntityDomain_d968b15b-b97f-4a62-9ef2-a03cb1101bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AHACMember_1ced4dfd-4e12-4fc2-b9d2-0f42f413781a" xlink:href="huma-20220630.xsd#huma_AHACMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_d968b15b-b97f-4a62-9ef2-a03cb1101bd4" xlink:to="loc_huma_AHACMember_1ced4dfd-4e12-4fc2-b9d2-0f42f413781a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_c592cd1c-5382-4905-9cc5-3bdfaabd5df3" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationTable_f68fa47f-7b25-4852-803d-675b5d316303" xlink:to="loc_srt_CounterpartyNameAxis_c592cd1c-5382-4905-9cc5-3bdfaabd5df3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_552cd100-51b0-4a2a-891f-e8df5f0534f4" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_c592cd1c-5382-4905-9cc5-3bdfaabd5df3" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_552cd100-51b0-4a2a-891f-e8df5f0534f4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CommonShareholdersMember_f72e3f92-968d-4910-b53a-78d658d23b94" xlink:href="huma-20220630.xsd#huma_CommonShareholdersMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_552cd100-51b0-4a2a-891f-e8df5f0534f4" xlink:to="loc_huma_CommonShareholdersMember_f72e3f92-968d-4910-b53a-78d658d23b94" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AHACFoundersMember_6edb1294-0603-4862-8f67-894d07611b7a" xlink:href="huma-20220630.xsd#huma_AHACFoundersMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_552cd100-51b0-4a2a-891f-e8df5f0534f4" xlink:to="loc_huma_AHACFoundersMember_6edb1294-0603-4862-8f67-894d07611b7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:href="huma-20220630.xsd#huma_ScheduleOfReverseRecapitalizationLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationTable_f68fa47f-7b25-4852-803d-675b5d316303" xlink:to="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_7bb25f12-1890-49ed-aa73-90bad887889e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_7bb25f12-1890-49ed-aa73-90bad887889e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockRepurchasedDuringPeriodShares_d6bdf830-0037-4000-8028-6edc164587f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockRepurchasedDuringPeriodShares"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_us-gaap_StockRepurchasedDuringPeriodShares_d6bdf830-0037-4000-8028-6edc164587f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_ec0150da-a0c8-4191-b7de-86b11e0c0a91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesAcquisitions"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesAcquisitions_ec0150da-a0c8-4191-b7de-86b11e0c0a91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_4b9ed886-0643-4efc-8fa8-bffbcb2b484a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesNewIssues"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesNewIssues_4b9ed886-0643-4efc-8fa8-bffbcb2b484a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_StockIssuedDuringPeriodSharesReverseRecapitalization_c9047615-a081-49da-a37b-f9ebaad391ce" xlink:href="huma-20220630.xsd#huma_StockIssuedDuringPeriodSharesReverseRecapitalization"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_huma_StockIssuedDuringPeriodSharesReverseRecapitalization_c9047615-a081-49da-a37b-f9ebaad391ce" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_StockConvertedReverseRecapitalization_a6bea648-945b-4a8b-94c7-e4c3d158ceec" xlink:href="huma-20220630.xsd#huma_StockConvertedReverseRecapitalization"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_huma_StockConvertedReverseRecapitalization_a6bea648-945b-4a8b-94c7-e4c3d158ceec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_StockIssuedDuringPeriodSharesConversionMergerAndRelatedPipeFinancing_ce84f5da-fb5c-4541-80b9-1189b2582f0e" xlink:href="huma-20220630.xsd#huma_StockIssuedDuringPeriodSharesConversionMergerAndRelatedPipeFinancing"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ScheduleOfReverseRecapitalizationLineItems_6da73a25-556f-4490-b1ab-852251aff2cb" xlink:to="loc_huma_StockIssuedDuringPeriodSharesConversionMergerAndRelatedPipeFinancing_ce84f5da-fb5c-4541-80b9-1189b2582f0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurements" xlink:type="simple" xlink:href="huma-20220630.xsd#FairValueMeasurements"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurements" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_eef52240-4f69-4072-b06e-428e0e217b99" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresTextBlock_f34c364c-9c4b-48d4-8d35-f94fe661c3bd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_eef52240-4f69-4072-b06e-428e0e217b99" xlink:to="loc_us-gaap_FairValueDisclosuresTextBlock_f34c364c-9c4b-48d4-8d35-f94fe661c3bd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurementsTables" xlink:type="simple" xlink:href="huma-20220630.xsd#FairValueMeasurementsTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurementsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_feeeda31-591e-40be-92bc-22165b73bed5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_2e41f09d-ef81-4570-b581-c5926c136f45" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_feeeda31-591e-40be-92bc-22165b73bed5" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTableTextBlock_2e41f09d-ef81-4570-b581-c5926c136f45" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_2db5df0c-9847-4bae-ad07-21f58a1e3fab" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_feeeda31-591e-40be-92bc-22165b73bed5" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTextBlock_2db5df0c-9847-4bae-ad07-21f58a1e3fab" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurementsAssetsandLiabilitiesMeasuredatFairValueonRecurringBasisDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_67e23270-ef3d-4d63-8167-1bdb92b5ccde" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_67e23270-ef3d-4d63-8167-1bdb92b5ccde" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6e00d435-1f28-4b27-be91-a893ba23efbd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByMeasurementFrequencyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:to="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6e00d435-1f28-4b27-be91-a893ba23efbd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementFrequencyDomain_3097f380-86d5-4313-8fee-096d637c4f4b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementFrequencyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByMeasurementFrequencyAxis_6e00d435-1f28-4b27-be91-a893ba23efbd" xlink:to="loc_us-gaap_FairValueMeasurementFrequencyDomain_3097f380-86d5-4313-8fee-096d637c4f4b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsRecurringMember_a29885b9-2bb9-41be-b48d-f28767bb8789" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsRecurringMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementFrequencyDomain_3097f380-86d5-4313-8fee-096d637c4f4b" xlink:to="loc_us-gaap_FairValueMeasurementsRecurringMember_a29885b9-2bb9-41be-b48d-f28767bb8789" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsAxis_995af29e-d9a8-4f50-ac24-0a09efae51b7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:to="loc_us-gaap_CashAndCashEquivalentsAxis_995af29e-d9a8-4f50-ac24-0a09efae51b7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e179b945-0c8e-4d0b-abda-8045eb7284de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CashAndCashEquivalentsAxis_995af29e-d9a8-4f50-ac24-0a09efae51b7" xlink:to="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e179b945-0c8e-4d0b-abda-8045eb7284de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MoneyMarketFundsMember_7caa60dd-7013-4616-96f5-087d630d4a2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MoneyMarketFundsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e179b945-0c8e-4d0b-abda-8045eb7284de" xlink:to="loc_us-gaap_MoneyMarketFundsMember_7caa60dd-7013-4616-96f5-087d630d4a2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CertificatesOfDepositMember_9f7759e3-7c43-4677-8410-4e5ef6f57d41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CertificatesOfDepositMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RestrictedCashAndCashEquivalentsCashAndCashEquivalentsMember_e179b945-0c8e-4d0b-abda-8045eb7284de" xlink:to="loc_us-gaap_CertificatesOfDepositMember_9f7759e3-7c43-4677-8410-4e5ef6f57d41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_59eef6ac-4c2b-403f-bfe5-4cefde002a97" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByFairValueHierarchyLevelAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:to="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_59eef6ac-4c2b-403f-bfe5-4cefde002a97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_548429e6-c616-4b17-89af-53709d706c1c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementsFairValueHierarchyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByFairValueHierarchyLevelAxis_59eef6ac-4c2b-403f-bfe5-4cefde002a97" xlink:to="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_548429e6-c616-4b17-89af-53709d706c1c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel1Member_aa4caf1f-f9b6-4e77-b7f8-bc3783d60510" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel1Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_548429e6-c616-4b17-89af-53709d706c1c" xlink:to="loc_us-gaap_FairValueInputsLevel1Member_aa4caf1f-f9b6-4e77-b7f8-bc3783d60510" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel2Member_a842772b-1071-46d1-b56e-4e08089ddedc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel2Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_548429e6-c616-4b17-89af-53709d706c1c" xlink:to="loc_us-gaap_FairValueInputsLevel2Member_a842772b-1071-46d1-b56e-4e08089ddedc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueInputsLevel3Member_dee565bb-d278-4c1c-8369-171cde02a838" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueInputsLevel3Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueMeasurementsFairValueHierarchyDomain_548429e6-c616-4b17-89af-53709d706c1c" xlink:to="loc_us-gaap_FairValueInputsLevel3Member_dee565bb-d278-4c1c-8369-171cde02a838" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3d4f336a-2718-4b5d-aa01-7cc1efeef715" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_beef19c8-5987-4655-881c-f2fe9c3aa39c" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3d4f336a-2718-4b5d-aa01-7cc1efeef715" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosureAbstract_01216f0f-63fe-44e1-996a-1d05e9692c7f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosureAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3d4f336a-2718-4b5d-aa01-7cc1efeef715" xlink:to="loc_us-gaap_AssetsFairValueDisclosureAbstract_01216f0f-63fe-44e1-996a-1d05e9692c7f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a419aea5-7dbc-462f-a760-a50624e1612d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CashAndCashEquivalentsFairValueDisclosure"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01216f0f-63fe-44e1-996a-1d05e9692c7f" xlink:to="loc_us-gaap_CashAndCashEquivalentsFairValueDisclosure_a419aea5-7dbc-462f-a760-a50624e1612d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_InvestmentsFairValueDisclosure_7911ff29-3ecb-42eb-b695-8c1018e13bd4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_InvestmentsFairValueDisclosure"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01216f0f-63fe-44e1-996a-1d05e9692c7f" xlink:to="loc_us-gaap_InvestmentsFairValueDisclosure_7911ff29-3ecb-42eb-b695-8c1018e13bd4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AssetsFairValueDisclosure_b36b5fdb-e362-4c2f-a20c-fd679087c624" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AssetsFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AssetsFairValueDisclosureAbstract_01216f0f-63fe-44e1-996a-1d05e9692c7f" xlink:to="loc_us-gaap_AssetsFairValueDisclosure_b36b5fdb-e362-4c2f-a20c-fd679087c624" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract_843bc97e-16b2-4ec2-be02-2f6b4e35f917" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_3d4f336a-2718-4b5d-aa01-7cc1efeef715" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract_843bc97e-16b2-4ec2-be02-2f6b4e35f917" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_b6ba62d2-5be9-4964-8654-2e3ea58b0a11" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiability"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract_843bc97e-16b2-4ec2-be02-2f6b4e35f917" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiability_b6ba62d2-5be9-4964-8654-2e3ea58b0a11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_1ab69ffb-9bd7-479d-80a4-d13c8a121ebe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract_843bc97e-16b2-4ec2-be02-2f6b4e35f917" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_1ab69ffb-9bd7-479d-80a4-d13c8a121ebe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_54b766ef-5ecc-4c51-b772-19ebb0a11b64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FinancialLiabilitiesFairValueDisclosure"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FinancialLiabilitiesFairValueDisclosureAbstract_843bc97e-16b2-4ec2-be02-2f6b4e35f917" xlink:to="loc_us-gaap_FinancialLiabilitiesFairValueDisclosure_54b766ef-5ecc-4c51-b772-19ebb0a11b64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurementsChangesinFairValueofLevel3FinancialInstrumentsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#FairValueMeasurementsChangesinFairValueofLevel3FinancialInstrumentsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurementsChangesinFairValueofLevel3FinancialInstrumentsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_8673d01f-a101-4adf-b9e6-8a779bc3d9b6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_940a194a-1fe8-4b2c-8a1b-37fdeffaf5a0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_8673d01f-a101-4adf-b9e6-8a779bc3d9b6" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_940a194a-1fe8-4b2c-8a1b-37fdeffaf5a0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_cff19fc5-14e4-4ca1-afec-7916421396dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_940a194a-1fe8-4b2c-8a1b-37fdeffaf5a0" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_cff19fc5-14e4-4ca1-afec-7916421396dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_50cfda5a-6a83-4963-800f-5cc41c3a07a1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_cff19fc5-14e4-4ca1-afec-7916421396dc" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_50cfda5a-6a83-4963-800f-5cc41c3a07a1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentEarnoutLiabilityMember_5ff89f86-2a75-4dd3-b23c-94d6ea95750d" xlink:href="huma-20220630.xsd#huma_ContingentEarnoutLiabilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_50cfda5a-6a83-4963-800f-5cc41c3a07a1" xlink:to="loc_huma_ContingentEarnoutLiabilityMember_5ff89f86-2a75-4dd3-b23c-94d6ea95750d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PrivatePlacementWarrantsMember_107a92c6-4223-4914-9e40-818bdf4f670c" xlink:href="huma-20220630.xsd#huma_PrivatePlacementWarrantsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_50cfda5a-6a83-4963-800f-5cc41c3a07a1" xlink:to="loc_huma_PrivatePlacementWarrantsMember_107a92c6-4223-4914-9e40-818bdf4f670c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_934b46e0-17dd-437d-b008-8b1bc0d0b404" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationTable_940a194a-1fe8-4b2c-8a1b-37fdeffaf5a0" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_934b46e0-17dd-437d-b008-8b1bc0d0b404" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_344bd59f-7e45-4f48-950e-14e36719d65e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationLineItems_934b46e0-17dd-437d-b008-8b1bc0d0b404" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_344bd59f-7e45-4f48-950e-14e36719d65e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_3b865040-d77c-484b-b062-69f6bc32e97e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_344bd59f-7e45-4f48-950e-14e36719d65e" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_3b865040-d77c-484b-b062-69f6bc32e97e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_227691fe-d47e-49c1-9d85-cb6801c6241e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_344bd59f-7e45-4f48-950e-14e36719d65e" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationRecurringBasisLiabilityGainLossIncludedInEarnings_227691fe-d47e-49c1-9d85-cb6801c6241e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6812db51-dc4d-4ac0-bd84-6acd138e428e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationCalculationRollForward_344bd59f-7e45-4f48-950e-14e36719d65e" xlink:to="loc_us-gaap_FairValueMeasurementWithUnobservableInputsReconciliationsRecurringBasisLiabilityValue_6812db51-dc4d-4ac0-bd84-6acd138e428e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedPeriodEndLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#FairValueMeasurementsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/FairValueMeasurementsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueDisclosuresAbstract_202776f6-5a6a-467b-a353-cc03b75cec37" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueDisclosuresAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_72f2271a-21c4-4383-b775-8c36dfcbd5c8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueDisclosuresAbstract_202776f6-5a6a-467b-a353-cc03b75cec37" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_72f2271a-21c4-4383-b775-8c36dfcbd5c8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueByLiabilityClassAxis_bae18d10-0559-401a-8dfb-a159e00d425f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueByLiabilityClassAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_72f2271a-21c4-4383-b775-8c36dfcbd5c8" xlink:to="loc_us-gaap_FairValueByLiabilityClassAxis_bae18d10-0559-401a-8dfb-a159e00d425f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_a905debf-c479-48ee-b8eb-93300324f3a4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueByLiabilityClassAxis_bae18d10-0559-401a-8dfb-a159e00d425f" xlink:to="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_a905debf-c479-48ee-b8eb-93300324f3a4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentEarnoutLiabilityMember_bbbf0873-1a33-4cfd-9bba-c9a12f77af7b" xlink:href="huma-20220630.xsd#huma_ContingentEarnoutLiabilityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueLiabilitiesMeasuredOnRecurringBasisUnobservableInputReconciliationByLiabilityClassDomain_a905debf-c479-48ee-b8eb-93300324f3a4" xlink:to="loc_huma_ContingentEarnoutLiabilityMember_bbbf0873-1a33-4cfd-9bba-c9a12f77af7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_4f80a8e4-24ef-4725-bfdb-39ffeef4f78a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_72f2271a-21c4-4383-b775-8c36dfcbd5c8" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_4f80a8e4-24ef-4725-bfdb-39ffeef4f78a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_e2365d7a-7334-42db-a707-93cb17a1b0de" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_4f80a8e4-24ef-4725-bfdb-39ffeef4f78a" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_e2365d7a-7334-42db-a707-93cb17a1b0de" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedTermMember_3390df68-a714-4fd3-b081-fe4fc9df5b82" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputExpectedTermMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_e2365d7a-7334-42db-a707-93cb17a1b0de" xlink:to="loc_us-gaap_MeasurementInputExpectedTermMember_3390df68-a714-4fd3-b081-fe4fc9df5b82" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_104ea30f-bac7-4604-acd2-addcf865b48a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisTable_72f2271a-21c4-4383-b775-8c36dfcbd5c8" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_104ea30f-bac7-4604-acd2-addcf865b48a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_0272151a-4266-487c-9d1b-34c54f169ae7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisLineItems_104ea30f-bac7-4604-acd2-addcf865b48a" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_0272151a-4266-487c-9d1b-34c54f169ae7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/PropertyandEquipmentNet" xlink:type="simple" xlink:href="huma-20220630.xsd#PropertyandEquipmentNet"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/PropertyandEquipmentNet" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1fa6d439-6449-41f2-b664-ba2de35c86da" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_18f9ed30-f77a-40fc-86be-016e44006e86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_1fa6d439-6449-41f2-b664-ba2de35c86da" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentDisclosureTextBlock_18f9ed30-f77a-40fc-86be-016e44006e86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/PropertyandEquipmentNetTables" xlink:type="simple" xlink:href="huma-20220630.xsd#PropertyandEquipmentNetTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/PropertyandEquipmentNetTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_37426dcf-49d3-45f2-bb70-40f6e28a1b92" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_32090139-7619-4c2d-a6cf-cce3f8c5c74e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_37426dcf-49d3-45f2-bb70-40f6e28a1b92" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTextBlock_32090139-7619-4c2d-a6cf-cce3f8c5c74e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/PropertyandEquipmentNetDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#PropertyandEquipmentNetDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/PropertyandEquipmentNetDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentAbstract_61bd2558-1476-4228-a6cd-ddf95c43091f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91e6970a-e1b1-4462-bada-a790276a0123" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfPropertyPlantAndEquipmentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentAbstract_61bd2558-1476-4228-a6cd-ddf95c43091f" xlink:to="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91e6970a-e1b1-4462-bada-a790276a0123" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2066fd7c-1655-4232-abd9-e0c85f7f90e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentByTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91e6970a-e1b1-4462-bada-a790276a0123" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2066fd7c-1655-4232-abd9-e0c85f7f90e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentByTypeAxis_2066fd7c-1655-4232-abd9-e0c85f7f90e2" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScientificEquipmentMember_4b9a6f9e-38b2-4804-8477-21ddaed70296" xlink:href="huma-20220630.xsd#huma_ScientificEquipmentMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_huma_ScientificEquipmentMember_4b9a6f9e-38b2-4804-8477-21ddaed70296" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ComputerEquipmentMember_f5353ebe-7716-460d-99b4-a698591e6318" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ComputerEquipmentMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_us-gaap_ComputerEquipmentMember_f5353ebe-7716-460d-99b4-a698591e6318" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SoftwareDevelopmentMember_a46a85e4-fa2a-4570-8755-226eec14d7ae" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SoftwareDevelopmentMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_us-gaap_SoftwareDevelopmentMember_a46a85e4-fa2a-4570-8755-226eec14d7ae" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FurnitureAndFixturesMember_a39d7303-2ea4-4d65-9077-08219dfa4573" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FurnitureAndFixturesMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_us-gaap_FurnitureAndFixturesMember_a39d7303-2ea4-4d65-9077-08219dfa4573" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LeaseholdImprovementsMember_922c5140-7ca9-4723-ba7e-f11d45e07c88" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LeaseholdImprovementsMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_us-gaap_LeaseholdImprovementsMember_922c5140-7ca9-4723-ba7e-f11d45e07c88" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScientificEquipmentNotPlacedIntoServiceMember_769e0087-9ccf-4e46-a594-725edea58238" xlink:href="huma-20220630.xsd#huma_ScientificEquipmentNotPlacedIntoServiceMember"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentTypeDomain_5334b56c-77cf-47b8-816e-434b2801ce7b" xlink:to="loc_huma_ScientificEquipmentNotPlacedIntoServiceMember_769e0087-9ccf-4e46-a594-725edea58238" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfPropertyPlantAndEquipmentTable_91e6970a-e1b1-4462-bada-a790276a0123" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentGross_09dd530b-9ae3-4c4d-aa2e-93b271eaa682" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentGross"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentGross_09dd530b-9ae3-4c4d-aa2e-93b271eaa682" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6fcc4c43-f0a6-4933-b8fb-2d1a094343ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:to="loc_us-gaap_AccumulatedDepreciationDepletionAndAmortizationPropertyPlantAndEquipment_6fcc4c43-f0a6-4933-b8fb-2d1a094343ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PropertyPlantAndEquipmentNet_3818e874-aa8b-49e6-b901-b4370a79d138" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PropertyPlantAndEquipmentNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:to="loc_us-gaap_PropertyPlantAndEquipmentNet_3818e874-aa8b-49e6-b901-b4370a79d138" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_Depreciation_0f6cced7-3885-4cfb-b1a5-baeb2f0087dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_Depreciation"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PropertyPlantAndEquipmentLineItems_f83c6234-fcd4-4998-bd9e-b49cfa0d9011" xlink:to="loc_us-gaap_Depreciation_0f6cced7-3885-4cfb-b1a5-baeb2f0087dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/AccruedExpenses" xlink:type="simple" xlink:href="huma-20220630.xsd#AccruedExpenses"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/AccruedExpenses" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_6ea24d2c-b123-4dc3-acca-df7778169ffe" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AccruedLiabilitiesDisclosureTextBlock_c74c887a-442d-4466-b279-45d13d02db47" xlink:href="huma-20220630.xsd#huma_AccruedLiabilitiesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_6ea24d2c-b123-4dc3-acca-df7778169ffe" xlink:to="loc_huma_AccruedLiabilitiesDisclosureTextBlock_c74c887a-442d-4466-b279-45d13d02db47" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/AccruedExpensesTables" xlink:type="simple" xlink:href="huma-20220630.xsd#AccruedExpensesTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/AccruedExpensesTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_f1e32470-2d32-4618-93a7-dc23a64248c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_49e9b81e-7e2d-4c02-ac4e-932e0c9b2f8e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_f1e32470-2d32-4618-93a7-dc23a64248c2" xlink:to="loc_us-gaap_ScheduleOfAccruedLiabilitiesTableTextBlock_49e9b81e-7e2d-4c02-ac4e-932e0c9b2f8e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/AccruedExpensesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#AccruedExpensesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/AccruedExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_7bcbcc73-67c3-49ca-9759-2627223b138a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrentAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent_f24c3085-5f68-4d18-a3a5-4756e354ba69" xlink:href="huma-20220630.xsd#huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_7bcbcc73-67c3-49ca-9759-2627223b138a" xlink:to="loc_huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent_f24c3085-5f68-4d18-a3a5-4756e354ba69" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_cc752ef7-8941-4b8f-8068-1aab440447cc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeRelatedLiabilitiesCurrent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_7bcbcc73-67c3-49ca-9759-2627223b138a" xlink:to="loc_us-gaap_EmployeeRelatedLiabilitiesCurrent_cc752ef7-8941-4b8f-8068-1aab440447cc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedProfessionalFeesCurrent_fbe63584-dfd7-43bf-b0ed-42c938075610" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedProfessionalFeesCurrent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_7bcbcc73-67c3-49ca-9759-2627223b138a" xlink:to="loc_us-gaap_AccruedProfessionalFeesCurrent_fbe63584-dfd7-43bf-b0ed-42c938075610" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AccruedLiabilitiesCurrent_2233692e-794e-4940-bb69-b0b66f680067" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AccruedLiabilitiesCurrent"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AccruedLiabilitiesCurrentAbstract_7bcbcc73-67c3-49ca-9759-2627223b138a" xlink:to="loc_us-gaap_AccruedLiabilitiesCurrent_2233692e-794e-4940-bb69-b0b66f680067" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/Debt" xlink:type="simple" xlink:href="huma-20220630.xsd#Debt"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/Debt" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_c2dd629b-d5fc-48ea-85d4-3c122e4dd75d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureTextBlock_ccb7c4d3-f299-4a07-b922-6a0d64cb2b13" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_c2dd629b-d5fc-48ea-85d4-3c122e4dd75d" xlink:to="loc_us-gaap_DebtDisclosureTextBlock_ccb7c4d3-f299-4a07-b922-6a0d64cb2b13" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtTables" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_efa52466-0e73-4564-b59c-f1e4106350a2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_813545cf-5ceb-475a-8fb8-abc61a178720" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfDebtInstrumentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_efa52466-0e73-4564-b59c-f1e4106350a2" xlink:to="loc_us-gaap_ScheduleOfDebtInstrumentsTextBlock_813545cf-5ceb-475a-8fb8-abc61a178720" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_a7278060-340d-4f05-9bd5-896147342cc9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_efa52466-0e73-4564-b59c-f1e4106350a2" xlink:to="loc_us-gaap_ScheduleOfMaturitiesOfLongTermDebtTableTextBlock_a7278060-340d-4f05-9bd5-896147342cc9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtPPPDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtPPPDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtPPPDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_6a08d2e2-0ac1-4ee5-87ab-e011d813dde0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_78faa03f-9519-44d0-bfb9-7ab155382483" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_6a08d2e2-0ac1-4ee5-87ab-e011d813dde0" xlink:to="loc_us-gaap_DebtInstrumentTable_78faa03f-9519-44d0-bfb9-7ab155382483" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_0f47b6ee-d9d7-4491-bf4a-eb2a51b85223" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_78faa03f-9519-44d0-bfb9-7ab155382483" xlink:to="loc_us-gaap_DebtInstrumentAxis_0f47b6ee-d9d7-4491-bf4a-eb2a51b85223" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_b1096069-08ce-42e2-80de-b4040313d6c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_0f47b6ee-d9d7-4491-bf4a-eb2a51b85223" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_b1096069-08ce-42e2-80de-b4040313d6c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PaycheckProtectionProgramMember_ab88c09a-4b31-4ec4-a17d-cad6ef1b74c6" xlink:href="huma-20220630.xsd#huma_PaycheckProtectionProgramMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_b1096069-08ce-42e2-80de-b4040313d6c1" xlink:to="loc_huma_PaycheckProtectionProgramMember_ab88c09a-4b31-4ec4-a17d-cad6ef1b74c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_9a5a6b39-f9bd-4a11-a6f2-da23dbd97659" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_78faa03f-9519-44d0-bfb9-7ab155382483" xlink:to="loc_us-gaap_DebtInstrumentLineItems_9a5a6b39-f9bd-4a11-a6f2-da23dbd97659" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_91dd1cb3-bc76-438a-8159-1b8e4a818159" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9a5a6b39-f9bd-4a11-a6f2-da23dbd97659" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_91dd1cb3-bc76-438a-8159-1b8e4a818159" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8adb64c0-eb08-4a7d-95d0-96661c7133e0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_9a5a6b39-f9bd-4a11-a6f2-da23dbd97659" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_8adb64c0-eb08-4a7d-95d0-96661c7133e0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtTermLoanDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtTermLoanDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtTermLoanDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_024899b2-7566-44fc-8384-03de5b424245" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_024899b2-7566-44fc-8384-03de5b424245" xlink:to="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_dde749d3-c496-442f-8330-5535d19d3f50" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_us-gaap_DebtInstrumentAxis_dde749d3-c496-442f-8330-5535d19d3f50" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_45bfdaf4-1c2e-4250-b499-806b63defb91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_dde749d3-c496-442f-8330-5535d19d3f50" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_45bfdaf4-1c2e-4250-b499-806b63defb91" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_TermLoanAgreementMember_bed43187-c0f8-4f2c-9662-86d0d46a1fb8" xlink:href="huma-20220630.xsd#huma_TermLoanAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_45bfdaf4-1c2e-4250-b499-806b63defb91" xlink:to="loc_huma_TermLoanAgreementMember_bed43187-c0f8-4f2c-9662-86d0d46a1fb8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PaycheckProtectionProgramMember_be8f32ef-af95-4281-80a5-ba142df3f747" xlink:href="huma-20220630.xsd#huma_PaycheckProtectionProgramMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_45bfdaf4-1c2e-4250-b499-806b63defb91" xlink:to="loc_huma_PaycheckProtectionProgramMember_be8f32ef-af95-4281-80a5-ba142df3f747" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityAxis_eac33e1f-d937-46b3-9950-870d23e9b5ed" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_us-gaap_LineOfCreditFacilityAxis_eac33e1f-d937-46b3-9950-870d23e9b5ed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLenderDomain_23ef423f-868e-4bf4-82c1-146da9ff55b4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLenderDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityAxis_eac33e1f-d937-46b3-9950-870d23e9b5ed" xlink:to="loc_us-gaap_LineOfCreditFacilityLenderDomain_23ef423f-868e-4bf4-82c1-146da9ff55b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember_07a6e41c-e648-421f-944b-cf59f9e0dcdb" xlink:href="huma-20220630.xsd#huma_SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLenderDomain_23ef423f-868e-4bf4-82c1-146da9ff55b4" xlink:to="loc_huma_SiliconValleyBankAndSVBInnovationCreditFundVIIILPMember_07a6e41c-e648-421f-944b-cf59f9e0dcdb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateAxis_8351a3e6-6e4b-4855-8abf-a85304c27d36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_us-gaap_VariableRateAxis_8351a3e6-6e4b-4855-8abf-a85304c27d36" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_VariableRateDomain_7c31500c-dc8d-4653-8bed-d0778918a683" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_VariableRateDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateAxis_8351a3e6-6e4b-4855-8abf-a85304c27d36" xlink:to="loc_us-gaap_VariableRateDomain_7c31500c-dc8d-4653-8bed-d0778918a683" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrimeRateMember_1f94b844-3eec-4398-a936-eaaf24fba7c2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrimeRateMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_VariableRateDomain_7c31500c-dc8d-4653-8bed-d0778918a683" xlink:to="loc_us-gaap_PrimeRateMember_1f94b844-3eec-4398-a936-eaaf24fba7c2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_5feb495f-c497-4c41-b854-62dfc2529d14" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_5feb495f-c497-4c41-b854-62dfc2529d14" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_2c5c3ff5-246e-43c1-8630-8194a7acdb27" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_5feb495f-c497-4c41-b854-62dfc2529d14" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_2c5c3ff5-246e-43c1-8630-8194a7acdb27" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_028cac5f-7f1d-4aaf-a635-3ee8a697b095" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_2c5c3ff5-246e-43c1-8630-8194a7acdb27" xlink:to="loc_us-gaap_WarrantMember_028cac5f-7f1d-4aaf-a635-3ee8a697b095" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePeriodAxis_90f66631-880a-43b2-92d3-2ec1bf250f6b" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePeriodAxis"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePeriodAxis_90f66631-880a-43b2-92d3-2ec1bf250f6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePeriodDomain_5067eba9-d5b5-4fc6-bd5a-c28567362be0" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePeriodDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_DebtInstrumentPrepaymentFeePeriodAxis_90f66631-880a-43b2-92d3-2ec1bf250f6b" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePeriodDomain_5067eba9-d5b5-4fc6-bd5a-c28567362be0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePeriodOneMember_381470e3-038b-44c7-b016-8c23635524ee" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePeriodOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_DebtInstrumentPrepaymentFeePeriodDomain_5067eba9-d5b5-4fc6-bd5a-c28567362be0" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePeriodOneMember_381470e3-038b-44c7-b016-8c23635524ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePeriodTwoMember_0fdd094d-2a89-42de-a658-6a2018e80c23" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePeriodTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_DebtInstrumentPrepaymentFeePeriodDomain_5067eba9-d5b5-4fc6-bd5a-c28567362be0" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePeriodTwoMember_0fdd094d-2a89-42de-a658-6a2018e80c23" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePeriodThreeMember_95f8aa34-8f4a-48c9-b0f8-b50f2e46888a" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePeriodThreeMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_DebtInstrumentPrepaymentFeePeriodDomain_5067eba9-d5b5-4fc6-bd5a-c28567362be0" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePeriodThreeMember_95f8aa34-8f4a-48c9-b0f8-b50f2e46888a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LineOfCreditFacilityLineItems"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityTable_5497e229-642d-46e1-b789-af6eca844afb" xlink:to="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentFaceAmount_9c60bcd3-e9f2-4219-bf07-300045439d24" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentFaceAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_DebtInstrumentFaceAmount_9c60bcd3-e9f2-4219-bf07-300045439d24" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPercentOfCollateralAmountInOutstandingPrincipalAndInterest_8590ea34-c13d-4929-8435-d108e35148e9" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPercentOfCollateralAmountInOutstandingPrincipalAndInterest"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentPercentOfCollateralAmountInOutstandingPrincipalAndInterest_8590ea34-c13d-4929-8435-d108e35148e9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_f227612c-5938-4c0e-8abc-dd3e1bbcd585" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfSecuredDebt"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfSecuredDebt_f227612c-5938-4c0e-8abc-dd3e1bbcd585" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentNumberOfTranches_f965539e-3447-45e8-87f7-c58f8269dcbc" xlink:href="huma-20220630.xsd#huma_DebtInstrumentNumberOfTranches"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentNumberOfTranches_f965539e-3447-45e8-87f7-c58f8269dcbc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentUnusedBorrowingCapacityAmountPerTranche_107b16d5-6db8-4884-9bea-95fc9ed8f31e" xlink:href="huma-20220630.xsd#huma_DebtInstrumentUnusedBorrowingCapacityAmountPerTranche"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentUnusedBorrowingCapacityAmountPerTranche_107b16d5-6db8-4884-9bea-95fc9ed8f31e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentInterestRateMinimumFixedRateOnVariableRate_56c2bb9e-1b21-4699-9585-3ba5a06dbbc4" xlink:href="huma-20220630.xsd#huma_DebtInstrumentInterestRateMinimumFixedRateOnVariableRate"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentInterestRateMinimumFixedRateOnVariableRate_56c2bb9e-1b21-4699-9585-3ba5a06dbbc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_b38ef1f7-b3ff-4ddb-b941-b9c5e5fed169" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentBasisSpreadOnVariableRate1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_DebtInstrumentBasisSpreadOnVariableRate1_b38ef1f7-b3ff-4ddb-b941-b9c5e5fed169" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_8029119f-cf72-4477-9534-3adc91fd04fc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentInterestRateEffectivePercentage"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_DebtInstrumentInterestRateEffectivePercentage_8029119f-cf72-4477-9534-3adc91fd04fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentAdvanceNoticePeriod_692d9c6a-961f-4a63-b078-49dcbbe29a97" xlink:href="huma-20220630.xsd#huma_DebtInstrumentAdvanceNoticePeriod"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentAdvanceNoticePeriod_692d9c6a-961f-4a63-b078-49dcbbe29a97" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentPrepaymentFeePercent_a53f345e-03e3-4527-a9f1-08b6a7ef8825" xlink:href="huma-20220630.xsd#huma_DebtInstrumentPrepaymentFeePercent"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentPrepaymentFeePercent_a53f345e-03e3-4527-a9f1-08b6a7ef8825" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_a1a95223-58be-48db-a96c-53f297721a64" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="11" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_a1a95223-58be-48db-a96c-53f297721a64" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ClassOfWarrantOrRightWarrantsExercisableImmediately_4284c94e-3f0a-4053-8aac-ad6622b4ff70" xlink:href="huma-20220630.xsd#huma_ClassOfWarrantOrRightWarrantsExercisableImmediately"/>
    <link:presentationArc order="12" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_ClassOfWarrantOrRightWarrantsExercisableImmediately_4284c94e-3f0a-4053-8aac-ad6622b4ff70" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ClassOfWarrantOrRightExercisableUponFundingOfAdditionalTranche_d1e261ed-13c0-4dfd-ae26-cc7b208001b4" xlink:href="huma-20220630.xsd#huma_ClassOfWarrantOrRightExercisableUponFundingOfAdditionalTranche"/>
    <link:presentationArc order="13" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_ClassOfWarrantOrRightExercisableUponFundingOfAdditionalTranche_d1e261ed-13c0-4dfd-ae26-cc7b208001b4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_253498d0-8b4e-4ba4-8acc-a5ca5ee8176e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="14" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_253498d0-8b4e-4ba4-8acc-a5ca5ee8176e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentFinalPaymentFeePercent_1b2fb96e-4118-4d23-b257-88f368deb67c" xlink:href="huma-20220630.xsd#huma_DebtInstrumentFinalPaymentFeePercent"/>
    <link:presentationArc order="15" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentFinalPaymentFeePercent_1b2fb96e-4118-4d23-b257-88f368deb67c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentFinalPaymentAmount_8f923553-1f3b-4628-8091-0cfcc5b2ed86" xlink:href="huma-20220630.xsd#huma_DebtInstrumentFinalPaymentAmount"/>
    <link:presentationArc order="16" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_huma_DebtInstrumentFinalPaymentAmount_8f923553-1f3b-4628-8091-0cfcc5b2ed86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AmortizationOfFinancingCosts_e706317a-e959-4626-83a4-43068b0c4be9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AmortizationOfFinancingCosts"/>
    <link:presentationArc order="17" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_AmortizationOfFinancingCosts_e706317a-e959-4626-83a4-43068b0c4be9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfDebt_25263139-1337-4921-a50a-6400fd027c74" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfDebt"/>
    <link:presentationArc order="18" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfDebt_25263139-1337-4921-a50a-6400fd027c74" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ed7fde3d-b62a-4e87-87cd-85fde9420349" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GainsLossesOnExtinguishmentOfDebt"/>
    <link:presentationArc order="19" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LineOfCreditFacilityLineItems_b9ec194f-bbd4-48e0-b563-69f7fe202d9e" xlink:to="loc_us-gaap_GainsLossesOnExtinguishmentOfDebt_ed7fde3d-b62a-4e87-87cd-85fde9420349" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_228aa4da-0020-412d-b885-29a7b4f460bc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentTable_5930ef4a-9874-423d-8774-f56cdf6c9623" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_228aa4da-0020-412d-b885-29a7b4f460bc" xlink:to="loc_us-gaap_DebtInstrumentTable_5930ef4a-9874-423d-8774-f56cdf6c9623" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentAxis_da6e63f4-806e-4ff7-b230-84000f2c8b42" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5930ef4a-9874-423d-8774-f56cdf6c9623" xlink:to="loc_us-gaap_DebtInstrumentAxis_da6e63f4-806e-4ff7-b230-84000f2c8b42" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentNameDomain_6ea60b32-db77-49c5-b8f1-3986fc99100d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentAxis_da6e63f4-806e-4ff7-b230-84000f2c8b42" xlink:to="loc_us-gaap_DebtInstrumentNameDomain_6ea60b32-db77-49c5-b8f1-3986fc99100d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_SVBLoanPayableMember_d92b25a6-66bd-4d35-ac3a-49a39ee5d8f8" xlink:href="huma-20220630.xsd#huma_SVBLoanPayableMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentNameDomain_6ea60b32-db77-49c5-b8f1-3986fc99100d" xlink:to="loc_huma_SVBLoanPayableMember_d92b25a6-66bd-4d35-ac3a-49a39ee5d8f8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentTable_5930ef4a-9874-423d-8774-f56cdf6c9623" xlink:to="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentCarryingAmount_d2995ecd-5bf2-4ef0-a96d-56f32f7d5271" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentCarryingAmount"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_us-gaap_DebtInstrumentCarryingAmount_d2995ecd-5bf2-4ef0-a96d-56f32f7d5271" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DebtInstrumentFinalPaymentAmount_4cdcb827-cb20-4efe-a706-4023879cc2ca" xlink:href="huma-20220630.xsd#huma_DebtInstrumentFinalPaymentAmount"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_huma_DebtInstrumentFinalPaymentAmount_4cdcb827-cb20-4efe-a706-4023879cc2ca" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_e9fd6bb0-1130-441b-8c65-9da178520933" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_us-gaap_DebtInstrumentUnamortizedDiscountPremiumAndDebtIssuanceCostsNet_e9fd6bb0-1130-441b-8c65-9da178520933" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_2c36243b-7e9b-4070-8e39-2d592f06fdee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_us-gaap_LongTermDebt_2c36243b-7e9b-4070-8e39-2d592f06fdee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtCurrent_7c5ea30f-b8a6-45d2-bd14-bb5b2aad9864" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtCurrent"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_us-gaap_LongTermDebtCurrent_7c5ea30f-b8a6-45d2-bd14-bb5b2aad9864" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtNoncurrent_41e7f38e-3679-4b1f-8cef-0884cbdce76d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtNoncurrent"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtInstrumentLineItems_a8a5105c-d2ca-4de5-83b0-e35f9b067a5a" xlink:to="loc_us-gaap_LongTermDebtNoncurrent_41e7f38e-3679-4b1f-8cef-0884cbdce76d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtSVBLoanPayableandNetDiscountorPremiumBalancesDetails_1" xlink:type="extended"/>
  <link:roleRef roleURI="http://www.humacyte.com/role/DebtFutureMinimumPaymentsofPrincipalDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#DebtFutureMinimumPaymentsofPrincipalDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/DebtFutureMinimumPaymentsofPrincipalDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DebtDisclosureAbstract_a7c1e053-6a9f-4522-8a2e-d5f38fb2cb4a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DebtDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtByMaturityAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DebtDisclosureAbstract_a7c1e053-6a9f-4522-8a2e-d5f38fb2cb4a" xlink:to="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_8222e419-9744-4139-adff-b5a718d09877" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalRemainderOfFiscalYear_8222e419-9744-4139-adff-b5a718d09877" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_03e3d898-f099-400c-bf79-9a87c3d88ebf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInNextTwelveMonths_03e3d898-f099-400c-bf79-9a87c3d88ebf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f403243d-d067-44ba-a78c-8bab24b48a86" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearTwo_f403243d-d067-44ba-a78c-8bab24b48a86" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5cad9b40-a754-4f0a-b5b7-00b2675f3637" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:to="loc_us-gaap_LongTermDebtMaturitiesRepaymentsOfPrincipalInYearThree_5cad9b40-a754-4f0a-b5b7-00b2675f3637" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_LongTermDebt_4bc7032a-cee0-43ff-9b59-fdfd062c9f5d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_LongTermDebt"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_LongTermDebtByMaturityAbstract_08fbcd25-451d-4424-a9a3-dd437eba2133" xlink:to="loc_us-gaap_LongTermDebt_4bc7032a-cee0-43ff-9b59-fdfd062c9f5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/totalLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficit" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficit"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficit" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_ce5f3439-bccd-4e06-9527-85417d75f532" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_7b4abfff-4336-47d3-9d30-fc068abe2092" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_ce5f3439-bccd-4e06-9527-85417d75f532" xlink:to="loc_us-gaap_StockholdersEquityNoteDisclosureTextBlock_7b4abfff-4336-47d3-9d30-fc068abe2092" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitTables" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_2bbc26ac-c2f4-449e-838f-3cf9e68756fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock_c6d5a158-004e-4ba1-963b-d064d53ba544" xlink:href="huma-20220630.xsd#huma_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_2bbc26ac-c2f4-449e-838f-3cf9e68756fb" xlink:to="loc_huma_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock_c6d5a158-004e-4ba1-963b-d064d53ba544" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_9cf5358d-ff5c-4905-8c1c-ffb444f08925" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_2bbc26ac-c2f4-449e-838f-3cf9e68756fb" xlink:to="loc_us-gaap_ScheduleOfStockholdersEquityNoteWarrantsOrRightsTextBlock_9cf5358d-ff5c-4905-8c1c-ffb444f08925" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_b31fe99b-447c-48a2-b646-b4bcc29fddf1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_2bbc26ac-c2f4-449e-838f-3cf9e68756fb" xlink:to="loc_us-gaap_FairValueAssetsAndLiabilitiesMeasuredOnRecurringAndNonrecurringBasisValuationTechniquesTableTextBlock_b31fe99b-447c-48a2-b646-b4bcc29fddf1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitCommonStockDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitCommonStockDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitCommonStockDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_ee8b327c-def0-4bba-8890-d4d8d856c365" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3036beb4-4c0e-4473-a6f1-5add82e6dd8f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_ee8b327c-def0-4bba-8890-d4d8d856c365" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3036beb4-4c0e-4473-a6f1-5add82e6dd8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementEquityComponentsAxis_efa2d4e1-c275-4bad-8a32-abef40bcd47e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementEquityComponentsAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3036beb4-4c0e-4473-a6f1-5add82e6dd8f" xlink:to="loc_us-gaap_StatementEquityComponentsAxis_efa2d4e1-c275-4bad-8a32-abef40bcd47e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityComponentDomain_76e27aad-b49e-40a9-b364-102c501cde39" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityComponentDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementEquityComponentsAxis_efa2d4e1-c275-4bad-8a32-abef40bcd47e" xlink:to="loc_us-gaap_EquityComponentDomain_76e27aad-b49e-40a9-b364-102c501cde39" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockMember_31764e90-5c71-4a59-bdb9-6ea10dbefab8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityComponentDomain_76e27aad-b49e-40a9-b364-102c501cde39" xlink:to="loc_us-gaap_CommonStockMember_31764e90-5c71-4a59-bdb9-6ea10dbefab8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_07f67d9d-341f-4f69-81df-16aaf44d6002" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3036beb4-4c0e-4473-a6f1-5add82e6dd8f" xlink:to="loc_us-gaap_TypeOfArrangementAxis_07f67d9d-341f-4f69-81df-16aaf44d6002" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddae6aac-df77-4c16-95c2-911c7e5399ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_07f67d9d-341f-4f69-81df-16aaf44d6002" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddae6aac-df77-4c16-95c2-911c7e5399ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember_2419530b-69cf-4278-b870-3aa3387fd46e" xlink:href="huma-20220630.xsd#huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_ddae6aac-df77-4c16-95c2-911c7e5399ef" xlink:to="loc_huma_AlphaHealthcareAcquisitionCorpAndHunterMergerSubIncMember_2419530b-69cf-4278-b870-3aa3387fd46e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionTable_3036beb4-4c0e-4473-a6f1-5add82e6dd8f" xlink:to="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_StockIssuedDuringPeriodSharesReverseRecapitalization_8ccc1860-421b-47b0-b633-e50c8b27b82a" xlink:href="huma-20220630.xsd#huma_StockIssuedDuringPeriodSharesReverseRecapitalization"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_huma_StockIssuedDuringPeriodSharesReverseRecapitalization_8ccc1860-421b-47b0-b633-e50c8b27b82a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_1a9e5fef-69aa-4927-9983-1d89d1598363" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfCommonStock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfCommonStock_1a9e5fef-69aa-4927-9983-1d89d1598363" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_TransactionCostsForRaisingCapital_5161930b-e4c5-41fb-bed6-eb289734d1a6" xlink:href="huma-20220630.xsd#huma_TransactionCostsForRaisingCapital"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_huma_TransactionCostsForRaisingCapital_5161930b-e4c5-41fb-bed6-eb289734d1a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2f646602-edc3-4380-8a24-94567696ac54" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedLiabilities_2f646602-edc3-4380-8a24-94567696ac54" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_dacb8a77-8a0e-424e-9e16-31f873dbe5ec" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_BusinessCombinationRecognizedIdentifiableAssetsAcquiredAndLiabilitiesAssumedAssets_dacb8a77-8a0e-424e-9e16-31f873dbe5ec" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesOutstanding_dbf92df0-152a-457f-9c95-994982d9eac6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesOutstanding"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_CommonStockSharesOutstanding_dbf92df0-152a-457f-9c95-994982d9eac6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockParOrStatedValuePerShare_e64ba763-4be4-4bbd-a219-d9fbf8fd622a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockParOrStatedValuePerShare"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_CommonStockParOrStatedValuePerShare_e64ba763-4be4-4bbd-a219-d9fbf8fd622a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesAuthorized_cf0c0514-a172-4672-90f0-f247aa9ada20" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesAuthorized"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_CommonStockSharesAuthorized_cf0c0514-a172-4672-90f0-f247aa9ada20" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DividendsCommonStock_54077a14-fdbd-4f02-a5f2-5cda4d6ba64d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DividendsCommonStock"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_us-gaap_DividendsCommonStock_54077a14-fdbd-4f02-a5f2-5cda4d6ba64d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CommonStockNumberOfVotesPerUnitOfSharesHeld_93ade93d-95a7-4a4c-bedd-62410b6890d1" xlink:href="huma-20220630.xsd#huma_CommonStockNumberOfVotesPerUnitOfSharesHeld"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionLineItems_8ece5fa2-6783-4afb-b84b-b56a4a4ce0c6" xlink:to="loc_huma_CommonStockNumberOfVotesPerUnitOfSharesHeld_93ade93d-95a7-4a4c-bedd-62410b6890d1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitCommonstockforfutureissuancesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitCommonstockforfutureissuancesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitCommonstockforfutureissuancesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_7c43130e-d99a-498a-8c70-eaa0395db640" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfStockByClassTable_48da9ab4-a24e-41c0-bdfe-7c7759ce3af9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfStockByClassTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_7c43130e-d99a-498a-8c70-eaa0395db640" xlink:to="loc_us-gaap_ScheduleOfStockByClassTable_48da9ab4-a24e-41c0-bdfe-7c7759ce3af9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CapitalSharesReservedForFutureIssuanceAxis_1425732d-ad42-4ad7-bd8d-06a9f38ad0fc" xlink:href="huma-20220630.xsd#huma_CapitalSharesReservedForFutureIssuanceAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_48da9ab4-a24e-41c0-bdfe-7c7759ce3af9" xlink:to="loc_huma_CapitalSharesReservedForFutureIssuanceAxis_1425732d-ad42-4ad7-bd8d-06a9f38ad0fc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:href="huma-20220630.xsd#huma_CapitalSharesReservedForFutureIssuanceDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceAxis_1425732d-ad42-4ad7-bd8d-06a9f38ad0fc" xlink:to="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CommonStockReservedForContingentConsiderationSharesMember_3e179d96-5adb-47bc-aba8-81b82114994a" xlink:href="huma-20220630.xsd#huma_CommonStockReservedForContingentConsiderationSharesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:to="loc_huma_CommonStockReservedForContingentConsiderationSharesMember_3e179d96-5adb-47bc-aba8-81b82114994a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_32fd407b-16e7-45c4-bb9c-74ccab769ae3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:to="loc_us-gaap_EmployeeStockOptionMember_32fd407b-16e7-45c4-bb9c-74ccab769ae3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_IssuanceOfOptionsUnderStockPlanMember_6b6b0216-a8b7-42c3-a875-2bc2dd3ef749" xlink:href="huma-20220630.xsd#huma_IssuanceOfOptionsUnderStockPlanMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:to="loc_huma_IssuanceOfOptionsUnderStockPlanMember_6b6b0216-a8b7-42c3-a875-2bc2dd3ef749" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_SharesAvailableForGrantUnderESPPMember_f50e6cc0-b6e0-4d76-b0ad-816f40de3d1e" xlink:href="huma-20220630.xsd#huma_SharesAvailableForGrantUnderESPPMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:to="loc_huma_SharesAvailableForGrantUnderESPPMember_f50e6cc0-b6e0-4d76-b0ad-816f40de3d1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_98b5e3a6-6d70-429b-b252-ba5259c1bdf3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CapitalSharesReservedForFutureIssuanceDomain_a5dac8a4-345b-46f9-bed6-d39b4c82f17d" xlink:to="loc_us-gaap_WarrantMember_98b5e3a6-6d70-429b-b252-ba5259c1bdf3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockLineItems_b613ec24-abb2-44f9-893c-100a9ab28ed6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfStockByClassTable_48da9ab4-a24e-41c0-bdfe-7c7759ce3af9" xlink:to="loc_us-gaap_ClassOfStockLineItems_b613ec24-abb2-44f9-893c-100a9ab28ed6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_c1fbb026-f4b4-4513-b9b1-d4c38ca4e06f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockCapitalSharesReservedForFutureIssuance"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockLineItems_b613ec24-abb2-44f9-893c-100a9ab28ed6" xlink:to="loc_us-gaap_CommonStockCapitalSharesReservedForFutureIssuance_c1fbb026-f4b4-4513-b9b1-d4c38ca4e06f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitPreferredStockDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitPreferredStockDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitPreferredStockDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_14012c6b-7aa2-4926-b35c-26e425ee2df6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockParOrStatedValuePerShare_2a13240c-92ef-4fa1-8d95-67f22ba645db" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockParOrStatedValuePerShare"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_14012c6b-7aa2-4926-b35c-26e425ee2df6" xlink:to="loc_us-gaap_PreferredStockParOrStatedValuePerShare_2a13240c-92ef-4fa1-8d95-67f22ba645db" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesAuthorized_6d02ad53-246b-45f9-ae4d-d5043d938701" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesAuthorized"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_14012c6b-7aa2-4926-b35c-26e425ee2df6" xlink:to="loc_us-gaap_PreferredStockSharesAuthorized_6d02ad53-246b-45f9-ae4d-d5043d938701" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PreferredStockSharesOutstanding_1b9d24e1-c088-4625-98ad-daf1c5666ced" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PreferredStockSharesOutstanding"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_14012c6b-7aa2-4926-b35c-26e425ee2df6" xlink:to="loc_us-gaap_PreferredStockSharesOutstanding_1b9d24e1-c088-4625-98ad-daf1c5666ced" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitWarrantsNarrativeDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitWarrantsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitWarrantsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EquityAbstract_a77373f7-4689-4f2b-8bbb-8499d3305ecb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EquityAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EquityAbstract_a77373f7-4689-4f2b-8bbb-8499d3305ecb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAxis_1f155a9c-b3c0-475b-9a77-a79b04565248" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:to="loc_us-gaap_BusinessAcquisitionAxis_1f155a9c-b3c0-475b-9a77-a79b04565248" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f59ed4f1-c3d9-4bd9-90f5-b8a1acef03f9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionAcquireeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAxis_1f155a9c-b3c0-475b-9a77-a79b04565248" xlink:to="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f59ed4f1-c3d9-4bd9-90f5-b8a1acef03f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_MergerAgreementMember_afbd53c2-0827-49ac-bf1d-20491b15a196" xlink:href="huma-20220630.xsd#huma_MergerAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionAcquireeDomain_f59ed4f1-c3d9-4bd9-90f5-b8a1acef03f9" xlink:to="loc_huma_MergerAgreementMember_afbd53c2-0827-49ac-bf1d-20491b15a196" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StatementClassOfStockAxis_873c5906-0c0e-4007-b72c-8bcbd622dfcf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StatementClassOfStockAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:to="loc_us-gaap_StatementClassOfStockAxis_873c5906-0c0e-4007-b72c-8bcbd622dfcf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfStockDomain_461506dc-454d-4e4b-8d91-32eb6b4884aa" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfStockDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StatementClassOfStockAxis_873c5906-0c0e-4007-b72c-8bcbd622dfcf" xlink:to="loc_us-gaap_ClassOfStockDomain_461506dc-454d-4e4b-8d91-32eb6b4884aa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantMember_63a12512-b281-4b53-95b6-4752846f106f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfStockDomain_461506dc-454d-4e4b-8d91-32eb6b4884aa" xlink:to="loc_us-gaap_WarrantMember_63a12512-b281-4b53-95b6-4752846f106f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SubsidiarySaleOfStockAxis_e819b4a7-6558-4702-836b-50e7c7b3b173" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SubsidiarySaleOfStockAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:to="loc_us-gaap_SubsidiarySaleOfStockAxis_e819b4a7-6558-4702-836b-50e7c7b3b173" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SaleOfStockNameOfTransactionDomain_65f6b478-ab0c-4354-812d-71d329b46def" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SaleOfStockNameOfTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SubsidiarySaleOfStockAxis_e819b4a7-6558-4702-836b-50e7c7b3b173" xlink:to="loc_us-gaap_SaleOfStockNameOfTransactionDomain_65f6b478-ab0c-4354-812d-71d329b46def" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_AssumptionOfPubliclyTradedSecuritiesMember_1fce8f68-a7d4-486a-9a7d-7a3718f83f11" xlink:href="huma-20220630.xsd#huma_AssumptionOfPubliclyTradedSecuritiesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_65f6b478-ab0c-4354-812d-71d329b46def" xlink:to="loc_huma_AssumptionOfPubliclyTradedSecuritiesMember_1fce8f68-a7d4-486a-9a7d-7a3718f83f11" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PrivatePlacementMember_0fe3d585-8778-49f5-a5a8-e2c1dbfc6ee2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PrivatePlacementMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_SaleOfStockNameOfTransactionDomain_65f6b478-ab0c-4354-812d-71d329b46def" xlink:to="loc_us-gaap_PrivatePlacementMember_0fe3d585-8778-49f5-a5a8-e2c1dbfc6ee2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_7b953a57-4c4b-4e42-8ff8-c6e8f6cfb235" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_159bd1b5-ae0c-4061-9c39-0faa37653a26" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_7b953a57-4c4b-4e42-8ff8-c6e8f6cfb235" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_NumberOfWarrantsExercised_49c65a30-0226-43cd-acf7-597ba223ec72" xlink:href="huma-20220630.xsd#huma_NumberOfWarrantsExercised"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_7b953a57-4c4b-4e42-8ff8-c6e8f6cfb235" xlink:to="loc_huma_NumberOfWarrantsExercised_49c65a30-0226-43cd-acf7-597ba223ec72" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_94b18dbc-fb4a-460e-aeb6-674dcf4fc69d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_7b953a57-4c4b-4e42-8ff8-c6e8f6cfb235" xlink:to="loc_us-gaap_BusinessAcquisitionEquityInterestsIssuedOrIssuableNumberOfSharesIssued_94b18dbc-fb4a-460e-aeb6-674dcf4fc69d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_16f39be2-fe65-4385-99ac-9db958989202" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_7b953a57-4c4b-4e42-8ff8-c6e8f6cfb235" xlink:to="loc_us-gaap_ClassOfWarrantOrRightExercisePriceOfWarrantsOrRights1_16f39be2-fe65-4385-99ac-9db958989202" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitWarrantsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitWarrantsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitWarrantsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_dbda77bc-f927-4613-ade1-9e7f593804a5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_06ed9377-ca26-43a9-85f3-6d703d789e1e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_dbda77bc-f927-4613-ade1-9e7f593804a5" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_06ed9377-ca26-43a9-85f3-6d703d789e1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_eeab078f-ebf4-42ab-96cb-e57069365a4d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_06ed9377-ca26-43a9-85f3-6d703d789e1e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_eeab078f-ebf4-42ab-96cb-e57069365a4d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_93a5811a-e7d7-4dd2-86de-a6b559064512" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_eeab078f-ebf4-42ab-96cb-e57069365a4d" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_93a5811a-e7d7-4dd2-86de-a6b559064512" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PrivatePlacementWarrantsMember_32976833-3b8e-496a-be32-ff6084dee810" xlink:href="huma-20220630.xsd#huma_PrivatePlacementWarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_93a5811a-e7d7-4dd2-86de-a6b559064512" xlink:to="loc_huma_PrivatePlacementWarrantsMember_32976833-3b8e-496a-be32-ff6084dee810" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PublicWarrantsMember_9ed5a995-a5f4-4a09-9dc6-e8388657958a" xlink:href="huma-20220630.xsd#huma_PublicWarrantsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_93a5811a-e7d7-4dd2-86de-a6b559064512" xlink:to="loc_huma_PublicWarrantsMember_9ed5a995-a5f4-4a09-9dc6-e8388657958a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_LegalEntityAxis_578cb468-f876-4075-9343-20899958d342" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_LegalEntityAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_06ed9377-ca26-43a9-85f3-6d703d789e1e" xlink:to="loc_dei_LegalEntityAxis_578cb468-f876-4075-9343-20899958d342" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_dei_EntityDomain_99bd8199-2801-44d7-a01f-61851eefe325" xlink:href="https://xbrl.sec.gov/dei/2022/dei-2022.xsd#dei_EntityDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_LegalEntityAxis_578cb468-f876-4075-9343-20899958d342" xlink:to="loc_dei_EntityDomain_99bd8199-2801-44d7-a01f-61851eefe325" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_HumacyteIncMember_59ce0380-8686-4b10-993e-1babbb5dd029" xlink:href="huma-20220630.xsd#huma_HumacyteIncMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_dei_EntityDomain_99bd8199-2801-44d7-a01f-61851eefe325" xlink:to="loc_huma_HumacyteIncMember_59ce0380-8686-4b10-993e-1babbb5dd029" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_1bf91f57-9552-436d-9cc1-a57630bbc47a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_06ed9377-ca26-43a9-85f3-6d703d789e1e" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_1bf91f57-9552-436d-9cc1-a57630bbc47a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightOutstanding_62be09d6-447c-4e1c-b0f0-f76312b5ecd8" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_1bf91f57-9552-436d-9cc1-a57630bbc47a" xlink:to="loc_us-gaap_ClassOfWarrantOrRightOutstanding_62be09d6-447c-4e1c-b0f0-f76312b5ecd8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitPublicWarrantsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitPublicWarrantsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitPublicWarrantsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_3f95d815-ca5d-4457-9f21-b956649726c0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_98043836-df8e-428f-9919-105c2ccd057f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_3f95d815-ca5d-4457-9f21-b956649726c0" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_98043836-df8e-428f-9919-105c2ccd057f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_4a4b7708-a98f-4029-8b8f-93d34c4f7cba" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_98043836-df8e-428f-9919-105c2ccd057f" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_4a4b7708-a98f-4029-8b8f-93d34c4f7cba" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_70d461fa-2a35-4cab-b434-f1fbd17ffeb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_4a4b7708-a98f-4029-8b8f-93d34c4f7cba" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_70d461fa-2a35-4cab-b434-f1fbd17ffeb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PublicWarrantsMember_6a96b5f3-b936-4d06-a6c6-3098de05a4a5" xlink:href="huma-20220630.xsd#huma_PublicWarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_70d461fa-2a35-4cab-b434-f1fbd17ffeb9" xlink:to="loc_huma_PublicWarrantsMember_6a96b5f3-b936-4d06-a6c6-3098de05a4a5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_98043836-df8e-428f-9919-105c2ccd057f" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_b77184da-e120-432e-99f8-dabdd500c61e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstandingTerm"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_b77184da-e120-432e-99f8-dabdd500c61e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_NumberOfDaysWarrantsBecomeExercisableAfterCompletionOfMerger_aa106835-9951-4ab7-bf16-745f8eac5673" xlink:href="huma-20220630.xsd#huma_NumberOfDaysWarrantsBecomeExercisableAfterCompletionOfMerger"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:to="loc_huma_NumberOfDaysWarrantsBecomeExercisableAfterCompletionOfMerger_aa106835-9951-4ab7-bf16-745f8eac5673" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ClassOfWarrantOrRightRedemptionThreshold_83b5e44e-ea5c-4926-95e3-ab8a2564d4b3" xlink:href="huma-20220630.xsd#huma_ClassOfWarrantOrRightRedemptionThreshold"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:to="loc_huma_ClassOfWarrantOrRightRedemptionThreshold_83b5e44e-ea5c-4926-95e3-ab8a2564d4b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_WarrantsExercisedMinimumPercentOfOutstandingSharesToReceiveCash_01522724-6ac5-43f5-8a54-ed5b5d337a8f" xlink:href="huma-20220630.xsd#huma_WarrantsExercisedMinimumPercentOfOutstandingSharesToReceiveCash"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:to="loc_huma_WarrantsExercisedMinimumPercentOfOutstandingSharesToReceiveCash_01522724-6ac5-43f5-8a54-ed5b5d337a8f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_FairValuePerShareOnClosingDate_c1534b46-622c-41ca-8f9c-c914ad11a444" xlink:href="huma-20220630.xsd#huma_FairValuePerShareOnClosingDate"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_38ca61a7-42b8-4e3f-9da1-8af63fb3f4e4" xlink:to="loc_huma_FairValuePerShareOnClosingDate_c1534b46-622c-41ca-8f9c-c914ad11a444" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitPrivatePlacementWarrantsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitPrivatePlacementWarrantsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitPrivatePlacementWarrantsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_18ccbd3d-7484-4434-ad36-c24bc247f8fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightTable_7ad3850b-574f-4834-b640-2cb47a4a70ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_18ccbd3d-7484-4434-ad36-c24bc247f8fb" xlink:to="loc_us-gaap_ClassOfWarrantOrRightTable_7ad3850b-574f-4834-b640-2cb47a4a70ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightAxis_7b08378c-6632-4ee4-ac45-31d61827f6ac" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_7ad3850b-574f-4834-b640-2cb47a4a70ff" xlink:to="loc_us-gaap_ClassOfWarrantOrRightAxis_7b08378c-6632-4ee4-ac45-31d61827f6ac" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightDomain_d8ff1f05-51bb-4367-a84b-ec87e6dd7e03" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightAxis_7b08378c-6632-4ee4-ac45-31d61827f6ac" xlink:to="loc_us-gaap_ClassOfWarrantOrRightDomain_d8ff1f05-51bb-4367-a84b-ec87e6dd7e03" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_PrivatePlacementWarrantsMember_a03121de-cd03-4a9f-b8aa-58ab857c984c" xlink:href="huma-20220630.xsd#huma_PrivatePlacementWarrantsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightDomain_d8ff1f05-51bb-4367-a84b-ec87e6dd7e03" xlink:to="loc_huma_PrivatePlacementWarrantsMember_a03121de-cd03-4a9f-b8aa-58ab857c984c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_2a755167-9e99-4811-b0aa-de150959ef9b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_7ad3850b-574f-4834-b640-2cb47a4a70ff" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_2a755167-9e99-4811-b0aa-de150959ef9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_2a755167-9e99-4811-b0aa-de150959ef9b" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputSharePriceMember_224750e3-0903-4e97-91fd-b20b8c2fcfeb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputSharePriceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:to="loc_us-gaap_MeasurementInputSharePriceMember_224750e3-0903-4e97-91fd-b20b8c2fcfeb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExercisePriceMember_341210a2-c21e-47ac-a65d-ef0c567eedf0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputExercisePriceMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:to="loc_us-gaap_MeasurementInputExercisePriceMember_341210a2-c21e-47ac-a65d-ef0c567eedf0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_0797e37f-de05-4be8-9a6f-b9b034357fc4" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_0797e37f-de05-4be8-9a6f-b9b034357fc4" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_3aa1604b-b5fc-4738-b1fe-dd1fcd64dede" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_3aa1604b-b5fc-4738-b1fe-dd1fcd64dede" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_8ef67bd5-f966-4935-94f6-9b4eed9f1116" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_5c482398-3e8b-45f2-88da-0ca4ea569bb9" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_8ef67bd5-f966-4935-94f6-9b4eed9f1116" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ClassOfWarrantOrRightLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightTable_7ad3850b-574f-4834-b640-2cb47a4a70ff" xlink:to="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstanding_eec20d81-dc68-42ed-81fb-2e6b27c62970" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstanding"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstanding_eec20d81-dc68-42ed-81fb-2e6b27c62970" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_FairValueAdjustmentOfWarrants_36fc7d8d-b2bc-4702-a430-3a84eee4e6f1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_FairValueAdjustmentOfWarrants"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:to="loc_us-gaap_FairValueAdjustmentOfWarrants_36fc7d8d-b2bc-4702-a430-3a84eee4e6f1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_305df7fd-6378-4396-846b-115a41449716" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstandingMeasurementInput"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingMeasurementInput_305df7fd-6378-4396-846b-115a41449716" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_WarrantsAndRightsOutstandingTerm_866884cf-d8c3-4e2a-b9bd-a1114af5e591" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_WarrantsAndRightsOutstandingTerm"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ClassOfWarrantOrRightLineItems_853451b5-2e0c-454e-9b94-11f67554418e" xlink:to="loc_us-gaap_WarrantsAndRightsOutstandingTerm_866884cf-d8c3-4e2a-b9bd-a1114af5e591" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockholdersEquityDeficitContingentEarnoutLiabilityDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockholdersEquityDeficitContingentEarnoutLiabilityDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockholdersEquityDeficitContingentEarnoutLiabilityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockholdersEquityNoteAbstract_ac9f5f33-0be3-49a2-a3ca-c919e369c14d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockholdersEquityNoteAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_StockholdersEquityNoteAbstract_ac9f5f33-0be3-49a2-a3ca-c919e369c14d" xlink:to="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTranchesAxis_97a8609e-da08-4331-997c-a1f216abd158" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTranchesAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:to="loc_huma_ContingentConsiderationTranchesAxis_97a8609e-da08-4331-997c-a1f216abd158" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTranchesDomain_5fa099a2-47b7-43ab-8304-376a1ebb9338" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTranchesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesAxis_97a8609e-da08-4331-997c-a1f216abd158" xlink:to="loc_huma_ContingentConsiderationTranchesDomain_5fa099a2-47b7-43ab-8304-376a1ebb9338" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTrancheOneMember_fe1ff3c4-80c6-49b3-b803-9ef127209307" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTrancheOneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesDomain_5fa099a2-47b7-43ab-8304-376a1ebb9338" xlink:to="loc_huma_ContingentConsiderationTrancheOneMember_fe1ff3c4-80c6-49b3-b803-9ef127209307" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ContingentConsiderationTrancheTwoMember_047d50f3-77af-4e5c-a14c-33ffbee8f4f9" xlink:href="huma-20220630.xsd#huma_ContingentConsiderationTrancheTwoMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_ContingentConsiderationTranchesDomain_5fa099a2-47b7-43ab-8304-376a1ebb9338" xlink:to="loc_huma_ContingentConsiderationTrancheTwoMember_047d50f3-77af-4e5c-a14c-33ffbee8f4f9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeAxis_dc6f313f-39a5-408e-abce-f091762ee0f3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:to="loc_us-gaap_MeasurementInputTypeAxis_dc6f313f-39a5-408e-abce-f091762ee0f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeAxis_dc6f313f-39a5-408e-abce-f091762ee0f3" xlink:to="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputSharePriceMember_447e25b7-72d6-46a8-b89e-b87f3fe62d17" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputSharePriceMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:to="loc_us-gaap_MeasurementInputSharePriceMember_447e25b7-72d6-46a8-b89e-b87f3fe62d17" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputPriceVolatilityMember_29d3faab-6e0e-4cb4-b3c7-1309ef9c9e02" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputPriceVolatilityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:to="loc_us-gaap_MeasurementInputPriceVolatilityMember_29d3faab-6e0e-4cb4-b3c7-1309ef9c9e02" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_64c8319f-9100-49dc-ad0c-9bdd755c2d2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputRiskFreeInterestRateMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:to="loc_us-gaap_MeasurementInputRiskFreeInterestRateMember_64c8319f-9100-49dc-ad0c-9bdd755c2d2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedDividendRateMember_38ca9979-6046-4af0-bb4f-0882b6f6c242" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputExpectedDividendRateMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:to="loc_us-gaap_MeasurementInputExpectedDividendRateMember_38ca9979-6046-4af0-bb4f-0882b6f6c242" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_MeasurementInputExpectedTermMember_2a03a4e9-21e1-4aa5-97b8-bc10db2840c1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_MeasurementInputExpectedTermMember"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_MeasurementInputTypeDomain_0150118b-4b0a-4ff4-adac-3d7ea85f50cd" xlink:to="loc_us-gaap_MeasurementInputExpectedTermMember_2a03a4e9-21e1-4aa5-97b8-bc10db2840c1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationByTypeAxis_f9f18ba0-5c46-4969-ae90-81af0c199495" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationByTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:to="loc_us-gaap_ContingentConsiderationByTypeAxis_f9f18ba0-5c46-4969-ae90-81af0c199495" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ContingentConsiderationTypeDomain_e2e1a523-1b9d-42fc-a8dc-489391b8c333" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ContingentConsiderationTypeDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationByTypeAxis_f9f18ba0-5c46-4969-ae90-81af0c199495" xlink:to="loc_us-gaap_ContingentConsiderationTypeDomain_e2e1a523-1b9d-42fc-a8dc-489391b8c333" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_EarnoutSharesMember_81051c2a-4ccb-4b68-afeb-169d9dda75f0" xlink:href="huma-20220630.xsd#huma_EarnoutSharesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ContingentConsiderationTypeDomain_e2e1a523-1b9d-42fc-a8dc-489391b8c333" xlink:to="loc_huma_EarnoutSharesMember_81051c2a-4ccb-4b68-afeb-169d9dda75f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessAcquisitionContingentConsiderationLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfBusinessAcquisitionsByAcquisitionContingentConsiderationTable_d5cf26ba-f277-43ed-835f-8f1d20b0a1dc" xlink:to="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_6d18e943-1e07-4ac4-8a0a-836a438d1127" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityShares"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityShares_6d18e943-1e07-4ac4-8a0a-836a438d1127" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches_e9a941ab-e4ec-4fd3-99e3-8cbc73fc26a6" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityNumberOfTranches_e9a941ab-e4ec-4fd3-99e3-8cbc73fc26a6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche_7abca07e-eca8-4f33-b1ff-9f91d12172f3" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilitySharesPerTranche_7abca07e-eca8-4f33-b1ff-9f91d12172f3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare_f6e19521-6450-43c4-a9f4-13968c120d0e" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityPerShare_f6e19521-6450-43c4-a9f4-13968c120d0e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays_68865b2f-b8c6-485e-9b95-d0eb76e3b880" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfTradingDays_68865b2f-b8c6-485e-9b95-d0eb76e3b880" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod_cef68cee-1b4c-44cf-b629-c1d9819da0df" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod_cef68cee-1b4c-44cf-b629-c1d9819da0df" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized_5e5cfd0b-aa93-4cae-be86-73424a954fdc" xlink:href="huma-20220630.xsd#huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_huma_ReverseRecapitalizationContingentConsiderationLiabilityRecognized_5e5cfd0b-aa93-4cae-be86-73424a954fdc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_cd74a95b-9a60-40ba-8870-6f4df3f16ae9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityMeasurementInput_cd74a95b-9a60-40ba-8870-6f4df3f16ae9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_25ef713d-14fd-47ce-b525-9f1cb33edced" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationLiabilityNoncurrent_25ef713d-14fd-47ce-b525-9f1cb33edced" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_475ced17-5b49-4166-b841-9f1dd4b1ba5c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_BusinessAcquisitionContingentConsiderationLineItems_fbffd869-4930-47a5-a001-9c232549df2d" xlink:to="loc_us-gaap_BusinessCombinationContingentConsiderationArrangementsChangeInAmountOfContingentConsiderationLiability1_475ced17-5b49-4166-b841-9f1dd4b1ba5c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedTerseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensation" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensation"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensation" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b9befbdc-f6e2-4667-a31c-fdd4785f44b2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_6b64499c-511d-4cd4-ad72-e64f421d8a2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_b9befbdc-f6e2-4667-a31c-fdd4785f44b2" xlink:to="loc_us-gaap_DisclosureOfCompensationRelatedCostsShareBasedPaymentsTextBlock_6b64499c-511d-4cd4-ad72-e64f421d8a2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationTables" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_f2edb0af-dbf2-4da7-bfaf-6366557fec91" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_e9346688-d1bc-4ef4-b627-bd3feb909f12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_f2edb0af-dbf2-4da7-bfaf-6366557fec91" xlink:to="loc_us-gaap_ScheduleOfShareBasedPaymentAwardStockOptionsValuationAssumptionsTableTextBlock_e9346688-d1bc-4ef4-b627-bd3feb909f12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_db8cf89d-b9de-4cd6-ae2c-a2b1f8a477f7" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_f2edb0af-dbf2-4da7-bfaf-6366557fec91" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTextBlock_db8cf89d-b9de-4cd6-ae2c-a2b1f8a477f7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_5a8d033f-0437-4f58-a1e1-f6306e18086d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_f2edb0af-dbf2-4da7-bfaf-6366557fec91" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationStockOptionsActivityTableTextBlock_5a8d033f-0437-4f58-a1e1-f6306e18086d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationNarrativeDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_519c720c-8ea5-4acb-b0ff-4e3cc9e045d3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_519c720c-8ea5-4acb-b0ff-4e3cc9e045d3" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_f08cf20e-2a2f-465b-8b8c-8bb3ffbb3394" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:to="loc_srt_RangeAxis_f08cf20e-2a2f-465b-8b8c-8bb3ffbb3394" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_59a2d9c3-3c4d-4741-bf43-866b23a2e7fa" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_f08cf20e-2a2f-465b-8b8c-8bb3ffbb3394" xlink:to="loc_srt_RangeMember_59a2d9c3-3c4d-4741-bf43-866b23a2e7fa" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_4e236ef7-f5d5-4b2d-bc64-f3a57c758b07" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_59a2d9c3-3c4d-4741-bf43-866b23a2e7fa" xlink:to="loc_srt_MinimumMember_4e236ef7-f5d5-4b2d-bc64-f3a57c758b07" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_146ab068-7348-41b6-a547-3aef41cd13d7" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_59a2d9c3-3c4d-4741-bf43-866b23a2e7fa" xlink:to="loc_srt_MaximumMember_146ab068-7348-41b6-a547-3aef41cd13d7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameAxis_0c9660d2-d1f3-4811-b807-a92295abb616" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:to="loc_us-gaap_PlanNameAxis_0c9660d2-d1f3-4811-b807-a92295abb616" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_PlanNameDomain_a3f2a6b6-0157-479e-ba6c-fd5108dbabfd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_PlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameAxis_0c9660d2-d1f3-4811-b807-a92295abb616" xlink:to="loc_us-gaap_PlanNameDomain_a3f2a6b6-0157-479e-ba6c-fd5108dbabfd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_LongTermIncentivePlan2021Member_176029e0-c071-4fd9-a359-d64b30760332" xlink:href="huma-20220630.xsd#huma_LongTermIncentivePlan2021Member"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_a3f2a6b6-0157-479e-ba6c-fd5108dbabfd" xlink:to="loc_huma_LongTermIncentivePlan2021Member_176029e0-c071-4fd9-a359-d64b30760332" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_OmnibusIncentivePlan2015Member_27719d6c-79c5-488a-8388-cf7410e7a779" xlink:href="huma-20220630.xsd#huma_OmnibusIncentivePlan2015Member"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_a3f2a6b6-0157-479e-ba6c-fd5108dbabfd" xlink:to="loc_huma_OmnibusIncentivePlan2015Member_27719d6c-79c5-488a-8388-cf7410e7a779" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_StockOptionPlan2005Member_093ca690-9db3-4fbc-958a-36026f6ac3b3" xlink:href="huma-20220630.xsd#huma_StockOptionPlan2005Member"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_PlanNameDomain_a3f2a6b6-0157-479e-ba6c-fd5108dbabfd" xlink:to="loc_huma_StockOptionPlan2005Member_093ca690-9db3-4fbc-958a-36026f6ac3b3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_c2fd200c-a8ac-4348-9d0d-a800531c8835" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:to="loc_us-gaap_AwardTypeAxis_c2fd200c-a8ac-4348-9d0d-a800531c8835" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_10adefe3-9b6c-46f1-86a0-b398cedd7b12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_c2fd200c-a8ac-4348-9d0d-a800531c8835" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_10adefe3-9b6c-46f1-86a0-b398cedd7b12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockMember_0b025264-2965-44a2-ac87-35c275d80e8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_10adefe3-9b6c-46f1-86a0-b398cedd7b12" xlink:to="loc_us-gaap_EmployeeStockMember_0b025264-2965-44a2-ac87-35c275d80e8d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_3e4525ee-83ea-49c0-81fb-42182b0a2f22" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_10adefe3-9b6c-46f1-86a0-b398cedd7b12" xlink:to="loc_us-gaap_EmployeeStockOptionMember_3e4525ee-83ea-49c0-81fb-42182b0a2f22" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_0b007c3d-b303-41c8-b4bf-6c93e903ba7a" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_b0fa84b1-cafd-4841-ac64-5e9eb96cfd41" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrant_b0fa84b1-cafd-4841-ac64-5e9eb96cfd41" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent_8ac8244d-d7d3-417c-b65a-80492cfd0cf7" xlink:href="huma-20220630.xsd#huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent_8ac8244d-d7d3-417c-b65a-80492cfd0cf7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_87c560c5-9cb6-4f00-997c-be061a680d6b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardPurchasePriceOfCommonStockPercent_87c560c5-9cb6-4f00-997c-be061a680d6b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans_b3222d07-db60-46eb-893e-137920810eed" xlink:href="huma-20220630.xsd#huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfPlans_b3222d07-db60-46eb-893e-137920810eed" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_e2a94ac6-193a-476d-9de9-e1da8a734c2f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_e2a94ac6-193a-476d-9de9-e1da8a734c2f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_1fde2846-a758-4e3d-ac95-9b9fe507bc34" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardExpirationPeriod_1fde2846-a758-4e3d-ac95-9b9fe507bc34" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_2264f988-61a9-41c5-8acc-0f60bcdbe0ef" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardAwardVestingPeriod1_2264f988-61a9-41c5-8acc-0f60bcdbe0ef" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod_70e4628e-5479-4ef3-b1dc-65a8e2b51c81" xlink:href="huma-20220630.xsd#huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod_70e4628e-5479-4ef3-b1dc-65a8e2b51c81" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingEndingPeriod_eb943769-5bed-455e-82c7-13cc5da08118" xlink:href="huma-20220630.xsd#huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingEndingPeriod"/>
    <link:presentationArc order="9" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingEndingPeriod_eb943769-5bed-455e-82c7-13cc5da08118" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_888f4a7f-d058-4097-bb93-c1fc32c7839e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="10" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_815d53c1-b00c-4c45-8fbe-e1b1575e2602" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_888f4a7f-d058-4097-bb93-c1fc32c7839e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationAssumptionsUsedtoEstimateFairValueofStockOptionsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationAssumptionsUsedtoEstimateFairValueofStockOptionsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationAssumptionsUsedtoEstimateFairValueofStockOptionsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4677c7fd-c9ad-4d63-93ee-783f0000302c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8b78a58d-e6b1-4dff-9130-6da14073bfff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_4677c7fd-c9ad-4d63-93ee-783f0000302c" xlink:to="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8b78a58d-e6b1-4dff-9130-6da14073bfff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AwardTypeAxis_1bbfe90b-03c2-4ed8-83fd-f9efbe69fce2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AwardTypeAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8b78a58d-e6b1-4dff-9130-6da14073bfff" xlink:to="loc_us-gaap_AwardTypeAxis_1bbfe90b-03c2-4ed8-83fd-f9efbe69fce2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ec9b9485-6b23-4b2a-99d3-d0e511794d63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_AwardTypeAxis_1bbfe90b-03c2-4ed8-83fd-f9efbe69fce2" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ec9b9485-6b23-4b2a-99d3-d0e511794d63" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeStockOptionMember_edd397be-e353-4114-aa1c-91adec41e89a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeStockOptionMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardAwardTypeAndPlanNameDomain_ec9b9485-6b23-4b2a-99d3-d0e511794d63" xlink:to="loc_us-gaap_EmployeeStockOptionMember_edd397be-e353-4114-aa1c-91adec41e89a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeAxis_d44f3e0e-4a21-49cb-8709-32c0ca91620a" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8b78a58d-e6b1-4dff-9130-6da14073bfff" xlink:to="loc_srt_RangeAxis_d44f3e0e-4a21-49cb-8709-32c0ca91620a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RangeMember_4dff2f1d-07b6-4ae7-bdb6-572596bd8b9b" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RangeMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeAxis_d44f3e0e-4a21-49cb-8709-32c0ca91620a" xlink:to="loc_srt_RangeMember_4dff2f1d-07b6-4ae7-bdb6-572596bd8b9b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MinimumMember_ed823313-5544-463f-b2b8-2f10108da653" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MinimumMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_4dff2f1d-07b6-4ae7-bdb6-572596bd8b9b" xlink:to="loc_srt_MinimumMember_ed823313-5544-463f-b2b8-2f10108da653" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_MaximumMember_398eb73b-286b-47fc-a862-8b37a06bbe04" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_MaximumMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RangeMember_4dff2f1d-07b6-4ae7-bdb6-572596bd8b9b" xlink:to="loc_srt_MaximumMember_398eb73b-286b-47fc-a862-8b37a06bbe04" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_10395fed-4e02-47d9-a340-786601461d56" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfShareBasedCompensationArrangementsByShareBasedPaymentAwardTable_8b78a58d-e6b1-4dff-9130-6da14073bfff" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_10395fed-4e02-47d9-a340-786601461d56" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardLineItems_10395fed-4e02-47d9-a340-786601461d56" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_eb64f0a8-f189-400a-bb6d-adc1c2ca834f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedDividendRate_eb64f0a8-f189-400a-bb6d-adc1c2ca834f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_5773a081-bdb5-46d2-9837-41838cd576d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRate_5773a081-bdb5-46d2-9837-41838cd576d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_81baf348-569e-436c-a633-23a54ebc662b" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMinimum_81baf348-569e-436c-a633-23a54ebc662b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_932d334e-52a3-462d-b183-085fc0040328" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsExpectedVolatilityRateMaximum_932d334e-52a3-462d-b183-085fc0040328" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_8c7baa38-1b2f-47eb-b2c3-234a0a6bc1b5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRate_8c7baa38-1b2f-47eb-b2c3-234a0a6bc1b5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_a2d48627-ca85-49e0-9a36-e019ab5b57ff" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMinimum_a2d48627-ca85-49e0-9a36-e019ab5b57ff" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_c7db7edf-6365-43dd-a2a4-1a329832a0e2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsRiskFreeInterestRateMaximum_c7db7edf-6365-43dd-a2a4-1a329832a0e2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3f2e916f-21ca-45f0-95cb-f00927f73fcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1"/>
    <link:presentationArc order="8" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardFairValueAssumptionsAndMethodologyAbstract_841c10da-1f2d-4d65-8cfd-d72f27c50167" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardFairValueAssumptionsExpectedTerm1_3f2e916f-21ca-45f0-95cb-f00927f73fcb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationStockBasedCompensationExpenseDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationStockBasedCompensationExpenseDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationStockBasedCompensationExpenseDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_297e8336-e476-4399-abe7-283377583e36" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_904a28cb-b4fd-4efc-b34b-29a00a6ee791" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_297e8336-e476-4399-abe7-283377583e36" xlink:to="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_904a28cb-b4fd-4efc-b34b-29a00a6ee791" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationAxis_68451da1-3d49-4b35-8a13-528c58b24162" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_904a28cb-b4fd-4efc-b34b-29a00a6ee791" xlink:to="loc_us-gaap_IncomeStatementLocationAxis_68451da1-3d49-4b35-8a13-528c58b24162" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeStatementLocationDomain_da5d8e26-9d1f-4d1b-9a4d-a46c8171fb12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeStatementLocationDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationAxis_68451da1-3d49-4b35-8a13-528c58b24162" xlink:to="loc_us-gaap_IncomeStatementLocationDomain_da5d8e26-9d1f-4d1b-9a4d-a46c8171fb12" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ResearchAndDevelopmentExpenseMember_bd5e9d72-b7c9-481c-b37d-960b396023a3" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ResearchAndDevelopmentExpenseMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_da5d8e26-9d1f-4d1b-9a4d-a46c8171fb12" xlink:to="loc_us-gaap_ResearchAndDevelopmentExpenseMember_bd5e9d72-b7c9-481c-b37d-960b396023a3" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_GeneralAndAdministrativeExpenseMember_04bd4e0e-efa8-4956-b081-1303f2ef3dcc" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_GeneralAndAdministrativeExpenseMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeStatementLocationDomain_da5d8e26-9d1f-4d1b-9a4d-a46c8171fb12" xlink:to="loc_us-gaap_GeneralAndAdministrativeExpenseMember_04bd4e0e-efa8-4956-b081-1303f2ef3dcc" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2fafc188-7efa-422f-84ab-4e8d28ac16fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfEmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsTable_904a28cb-b4fd-4efc-b34b-29a00a6ee791" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2fafc188-7efa-422f-84ab-4e8d28ac16fd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_AllocatedShareBasedCompensationExpense_c83ba37b-09e6-424c-a9f8-d102a61be60e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_AllocatedShareBasedCompensationExpense"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_EmployeeServiceShareBasedCompensationAllocationOfRecognizedPeriodCostsLineItems_2fafc188-7efa-422f-84ab-4e8d28ac16fd" xlink:to="loc_us-gaap_AllocatedShareBasedCompensationExpense_c83ba37b-09e6-424c-a9f8-d102a61be60e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationRemainingUnrecognizedCostsDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationRemainingUnrecognizedCostsDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationRemainingUnrecognizedCostsDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_15c41c4f-0dec-4e4a-9f2e-2a4c15767a9d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_b8a3ecc9-5d36-416e-8d76-8f929a315d6c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_15c41c4f-0dec-4e4a-9f2e-2a4c15767a9d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedStockOptions_b8a3ecc9-5d36-416e-8d76-8f929a315d6c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4022862b-257a-4e69-b7b2-e997a88f5259" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_15c41c4f-0dec-4e4a-9f2e-2a4c15767a9d" xlink:to="loc_us-gaap_EmployeeServiceShareBasedCompensationNonvestedAwardsTotalCompensationCostNotYetRecognizedPeriodForRecognition1_4022862b-257a-4e69-b7b2-e997a88f5259" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/StockbasedCompensationStockOptionActivityDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#StockbasedCompensationStockOptionActivityDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/StockbasedCompensationStockOptionActivityDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2f47b135-342d-49dc-aee9-32e6036a2edf" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_2f47b135-342d-49dc-aee9-32e6036a2edf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_7f636a97-f02e-4a04-9123-2f1e1ccbd069" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsGrantsInPeriodGross_7f636a97-f02e-4a04-9123-2f1e1ccbd069" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_afab5a52-5d23-4e4e-a873-af7a7a931db2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:to="loc_us-gaap_StockIssuedDuringPeriodSharesStockOptionsExercised_afab5a52-5d23-4e4e-a873-af7a7a931db2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_319cdac0-e75f-40bf-8a2d-99440118d205" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsForfeituresInPeriod_319cdac0-e75f-40bf-8a2d-99440118d205" xlink:type="arc" preferredLabel="http://www.xbrl.org/2009/role/negatedLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_9c2f0c04-d18a-47c0-8737-9845c32635ea" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingRollForward_7bb3fab1-882a-42fc-8fd5-ab278400e2bf" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingNumber_9c2f0c04-d18a-47c0-8737-9845c32635ea" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_e1be9988-4a70-428a-84bd-8ebf6100c996" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableNumber_e1be9988-4a70-428a-84bd-8ebf6100c996" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_0d8e8389-cc5a-4a87-97e3-16ce833be04a" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingNumber_0d8e8389-cc5a-4a87-97e3-16ce833be04a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_01311c79-83a7-4978-9fc3-641032bf49fb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_01311c79-83a7-4978-9fc3-641032bf49fb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodStartLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_91f0759f-6a76-4e14-8196-7c6a1c3c833d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsGrantsInPeriodWeightedAverageExercisePrice_91f0759f-6a76-4e14-8196-7c6a1c3c833d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_7047c20d-41bc-4f90-97aa-0b1d0fcd662f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsExercisesInPeriodWeightedAverageExercisePrice_7047c20d-41bc-4f90-97aa-0b1d0fcd662f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_6c9db884-da96-47d4-9f0c-8d19b09b08ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementsByShareBasedPaymentAwardOptionsForfeituresInPeriodWeightedAverageExercisePrice_6c9db884-da96-47d4-9f0c-8d19b09b08ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_24696b55-595b-4ae1-b5dc-87d5166df4e6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePriceRollforward_2a329aeb-a420-4794-81ec-fb36944d6367" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingWeightedAverageExercisePrice_24696b55-595b-4ae1-b5dc-87d5166df4e6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/periodEndLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_0fc9c293-1fcc-4667-bbc3-fc1e32332f57" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsExercisableWeightedAverageExercisePrice_0fc9c293-1fcc-4667-bbc3-fc1e32332f57" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_d065a3ca-8b7a-4fd8-8a76-46f7313bafcb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageExercisePrice_d065a3ca-8b7a-4fd8-8a76-46f7313bafcb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract"/>
    <link:presentationArc order="7" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_DisclosureOfCompensationRelatedCostsSharebasedPaymentsAbstract_0c19148b-77da-4c51-890a-4f04ea6ad7c5" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_1f5f0ecf-57a1-40a7-8343-2031dad649e5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsOutstandingWeightedAverageRemainingContractualTerm2_1f5f0ecf-57a1-40a7-8343-2031dad649e5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_f960c14e-7e1e-4325-b75c-b3c933259e30" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableWeightedAverageRemainingContractualTerm1_f960c14e-7e1e-4325-b75c-b3c933259e30" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_e72e0b44-dc8c-4a63-a89c-e138a3d24dd1" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingWeightedAverageRemainingContractualTerm1_e72e0b44-dc8c-4a63-a89c-e138a3d24dd1" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_efb41014-d220-42da-89c3-61bad6221638" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingIntrinsicValue_efb41014-d220-42da-89c3-61bad6221638" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_5254ea4d-e3d3-47bb-9dbb-724e9257d7f0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_SharebasedCompensationArrangementBySharebasedPaymentAwardOptionsExercisableIntrinsicValue1_5254ea4d-e3d3-47bb-9dbb-724e9257d7f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_e2f755e0-9d22-44d9-a4bb-5c42276cc5d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue"/>
    <link:presentationArc order="6" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsAdditionalDisclosuresAbstract_d7648930-90a9-45ff-a0f7-f6fb482c539e" xlink:to="loc_us-gaap_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsVestedAndExpectedToVestOutstandingAggregateIntrinsicValue_e2f755e0-9d22-44d9-a4bb-5c42276cc5d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/IncomeTaxes" xlink:type="simple" xlink:href="huma-20220630.xsd#IncomeTaxes"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/IncomeTaxes" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_1216faeb-f7a9-497b-99b2-689fecbc9b63" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureTextBlock_808df2f8-5ada-43e3-accb-3823094db61e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_1216faeb-f7a9-497b-99b2-689fecbc9b63" xlink:to="loc_us-gaap_IncomeTaxDisclosureTextBlock_808df2f8-5ada-43e3-accb-3823094db61e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/IncomeTaxesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#IncomeTaxesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/IncomeTaxesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxDisclosureAbstract_ffd974ab-1033-47ba-ac3e-b3689e21d4fd" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_d3d48755-4d97-4422-944d-60bfd2a61468" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_EffectiveIncomeTaxRateContinuingOperations"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_ffd974ab-1033-47ba-ac3e-b3689e21d4fd" xlink:to="loc_us-gaap_EffectiveIncomeTaxRateContinuingOperations_d3d48755-4d97-4422-944d-60bfd2a61468" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_IncomeTaxExpenseBenefit_21dd8363-78cd-4087-9159-6f08e241fff0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_IncomeTaxExpenseBenefit"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_IncomeTaxDisclosureAbstract_ffd974ab-1033-47ba-ac3e-b3689e21d4fd" xlink:to="loc_us-gaap_IncomeTaxExpenseBenefit_21dd8363-78cd-4087-9159-6f08e241fff0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CommitmentsandContingencies" xlink:type="simple" xlink:href="huma-20220630.xsd#CommitmentsandContingencies"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CommitmentsandContingencies" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_d9657796-b2db-45f4-a1fb-2dadd8844c8d" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2ab68c28-239a-4738-babf-1f109bb51ea5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_d9657796-b2db-45f4-a1fb-2dadd8844c8d" xlink:to="loc_us-gaap_CommitmentsAndContingenciesDisclosureTextBlock_2ab68c28-239a-4738-babf-1f109bb51ea5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/CommitmentsandContingenciesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#CommitmentsandContingenciesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/CommitmentsandContingenciesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9b82ba99-ecea-42b4-aad5-85a82b45bcd2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommitmentsAndContingenciesDisclosureAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CommitmentsAndContingenciesDisclosureAbstract_9b82ba99-ecea-42b4-aad5-85a82b45bcd2" xlink:to="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_CounterpartyNameAxis_5f980e99-4aa7-4b85-8003-8ea074016dbe" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_CounterpartyNameAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:to="loc_srt_CounterpartyNameAxis_5f980e99-4aa7-4b85-8003-8ea074016dbe" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_RepurchaseAgreementCounterpartyNameDomain_498882d0-2190-4582-9e64-43f053f41bd5" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_RepurchaseAgreementCounterpartyNameDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_CounterpartyNameAxis_5f980e99-4aa7-4b85-8003-8ea074016dbe" xlink:to="loc_srt_RepurchaseAgreementCounterpartyNameDomain_498882d0-2190-4582-9e64-43f053f41bd5" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DukeUniversityMember_a3410b01-a39a-46b4-b5a0-b4c0bfd21794" xlink:href="huma-20220630.xsd#huma_DukeUniversityMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_498882d0-2190-4582-9e64-43f053f41bd5" xlink:to="loc_huma_DukeUniversityMember_a3410b01-a39a-46b4-b5a0-b4c0bfd21794" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_YaleUniversityMember_a2295ed9-f12a-48c5-b69f-a69603161860" xlink:href="huma-20220630.xsd#huma_YaleUniversityMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_RepurchaseAgreementCounterpartyNameDomain_498882d0-2190-4582-9e64-43f053f41bd5" xlink:to="loc_huma_YaleUniversityMember_a2295ed9-f12a-48c5-b69f-a69603161860" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_TypeOfArrangementAxis_e750a68a-2d0a-4f28-8988-51b93badb52e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_TypeOfArrangementAxis"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:to="loc_us-gaap_TypeOfArrangementAxis_e750a68a-2d0a-4f28-8988-51b93badb52e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_405a3201-5ec7-49c6-b2d6-c20c8c8b19d0" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ArrangementsAndNonarrangementTransactionsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_TypeOfArrangementAxis_e750a68a-2d0a-4f28-8988-51b93badb52e" xlink:to="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_405a3201-5ec7-49c6-b2d6-c20c8c8b19d0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_LicenseAgreementMember_fbcbc89c-7103-415a-a6b6-7a8a05e9a2cd" xlink:href="huma-20220630.xsd#huma_LicenseAgreementMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ArrangementsAndNonarrangementTransactionsMember_405a3201-5ec7-49c6-b2d6-c20c8c8b19d0" xlink:to="loc_huma_LicenseAgreementMember_fbcbc89c-7103-415a-a6b6-7a8a05e9a2cd" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementMilestonePaymentsAxis_7763779a-df67-46a2-b47b-e8c0dd316905" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementMilestonePaymentsAxis"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:to="loc_huma_CollaborativeArrangementMilestonePaymentsAxis_7763779a-df67-46a2-b47b-e8c0dd316905" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementMilestonePaymentsDomain_4883fbb0-5f5d-45bb-a09e-8997e7b6c509" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementMilestonePaymentsDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CollaborativeArrangementMilestonePaymentsAxis_7763779a-df67-46a2-b47b-e8c0dd316905" xlink:to="loc_huma_CollaborativeArrangementMilestonePaymentsDomain_4883fbb0-5f5d-45bb-a09e-8997e7b6c509" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_RegulatoryMilestoneMember_2470a9dd-6c54-4aa0-a566-ce2c5ea85f5e" xlink:href="huma-20220630.xsd#huma_RegulatoryMilestoneMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CollaborativeArrangementMilestonePaymentsDomain_4883fbb0-5f5d-45bb-a09e-8997e7b6c509" xlink:to="loc_huma_RegulatoryMilestoneMember_2470a9dd-6c54-4aa0-a566-ce2c5ea85f5e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CommercialMilestoneMember_5b932074-6480-4aa2-b8f7-00a20deb85c7" xlink:href="huma-20220630.xsd#huma_CommercialMilestoneMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_huma_CollaborativeArrangementMilestonePaymentsDomain_4883fbb0-5f5d-45bb-a09e-8997e7b6c509" xlink:to="loc_huma_CommercialMilestoneMember_5b932074-6480-4aa2-b8f7-00a20deb85c7" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductOrServiceAxis_8e252a0a-96ae-4da5-92a5-f88d205ad4d8" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductOrServiceAxis"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:to="loc_srt_ProductOrServiceAxis_8e252a0a-96ae-4da5-92a5-f88d205ad4d8" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:href="https://xbrl.fasb.org/srt/2022/elts/srt-2022.xsd#srt_ProductsAndServicesDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductOrServiceAxis_8e252a0a-96ae-4da5-92a5-f88d205ad4d8" xlink:to="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DecellularizedTissueEngineeringPatentRightsMember_797417f6-4c92-4307-94a9-1841b681151c" xlink:href="huma-20220630.xsd#huma_DecellularizedTissueEngineeringPatentRightsMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:to="loc_huma_DecellularizedTissueEngineeringPatentRightsMember_797417f6-4c92-4307-94a9-1841b681151c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_SmallDiameterVesselsPatentRightsMember_acace025-33b5-4bb1-8b74-d022c22283a2" xlink:href="huma-20220630.xsd#huma_SmallDiameterVesselsPatentRightsMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:to="loc_huma_SmallDiameterVesselsPatentRightsMember_acace025-33b5-4bb1-8b74-d022c22283a2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_BVPPatentRightsMember_66805580-e344-4438-b0b6-1f3e1e099429" xlink:href="huma-20220630.xsd#huma_BVPPatentRightsMember"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:to="loc_huma_BVPPatentRightsMember_66805580-e344-4438-b0b6-1f3e1e099429" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_TubularProsthesesPatentRightsMember_2ae86e09-e070-4e16-b324-53e6e2bdef5d" xlink:href="huma-20220630.xsd#huma_TubularProsthesesPatentRightsMember"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_srt_ProductsAndServicesDomain_54e2800c-3b77-4569-862b-5b70ef4569f0" xlink:to="loc_huma_TubularProsthesesPatentRightsMember_2ae86e09-e070-4e16-b324-53e6e2bdef5d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfCollaborativeArrangementsAndNoncollaborativeArrangementTransactionsTable_8f6e03ee-0306-4073-86f9-7a7fa7aa19d5" xlink:to="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementSharesIssued_674e0181-4402-49cc-bce9-4ea3d11f2a5b" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementSharesIssued"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:to="loc_huma_CollaborativeArrangementSharesIssued_674e0181-4402-49cc-bce9-4ea3d11f2a5b" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementExpirationPeriod_77b97a2d-dcda-4054-a79b-3c092e552c1d" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementExpirationPeriod"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:to="loc_huma_CollaborativeArrangementExpirationPeriod_77b97a2d-dcda-4054-a79b-3c092e552c1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementTerminationPeriod_fbc5ebac-7b1f-4067-84b8-194b0e114faf" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementTerminationPeriod"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:to="loc_huma_CollaborativeArrangementTerminationPeriod_fbc5ebac-7b1f-4067-84b8-194b0e114faf" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementMaximumAnnualMaintenanceFee_27fa8e00-ba76-4e30-8528-f07fdc0264bb" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementMaximumAnnualMaintenanceFee"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:to="loc_huma_CollaborativeArrangementMaximumAnnualMaintenanceFee_27fa8e00-ba76-4e30-8528-f07fdc0264bb" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_CollaborativeArrangementMilestonePayments_c1848a2a-560d-4c8c-950a-287d9bceb86a" xlink:href="huma-20220630.xsd#huma_CollaborativeArrangementMilestonePayments"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_CollaborativeArrangementsAndNoncollaborativeArrangementTransactionsLineItems_2d06e7c0-1bf9-466a-ba07-68c8275a570f" xlink:to="loc_huma_CollaborativeArrangementMilestonePayments_c1848a2a-560d-4c8c-950a-287d9bceb86a" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/RelatedPartyTransactions" xlink:type="simple" xlink:href="huma-20220630.xsd#RelatedPartyTransactions"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/RelatedPartyTransactions" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_1c8b570d-253b-4950-bab1-1649ac752a12" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_60f1fc99-9551-4607-bce0-046c3089c751" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsDisclosureTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_1c8b570d-253b-4950-bab1-1649ac752a12" xlink:to="loc_us-gaap_RelatedPartyTransactionsDisclosureTextBlock_60f1fc99-9551-4607-bce0-046c3089c751" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/RelatedPartyTransactionsTables" xlink:type="simple" xlink:href="huma-20220630.xsd#RelatedPartyTransactionsTables"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/RelatedPartyTransactionsTables" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_071effa8-edf9-40cf-85bf-6dbf911126bb" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock_2812a859-9cd7-4b3a-b076-a0e0f0774275" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_071effa8-edf9-40cf-85bf-6dbf911126bb" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsTableTextBlock_2812a859-9cd7-4b3a-b076-a0e0f0774275" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#RelatedPartyTransactionsNarrativeDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/RelatedPartyTransactionsNarrativeDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_ee1ea033-f83b-4056-838d-4d0b41d4f479" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_ca12c3a3-e76c-4dd2-b114-3e1d6df96107" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_ee1ea033-f83b-4056-838d-4d0b41d4f479" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_ca12c3a3-e76c-4dd2-b114-3e1d6df96107" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_bb33c994-0fd9-4778-bec9-a645cc28b346" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsByRelatedPartyAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_ca12c3a3-e76c-4dd2-b114-3e1d6df96107" xlink:to="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_bb33c994-0fd9-4778-bec9-a645cc28b346" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyDomain_ec4ae2d8-7ada-45cb-b05e-bdf249270354" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsByRelatedPartyAxis_bb33c994-0fd9-4778-bec9-a645cc28b346" xlink:to="loc_us-gaap_RelatedPartyDomain_ec4ae2d8-7ada-45cb-b05e-bdf249270354" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_FreseniusMedicalCareMember_b01c68e5-52c0-4bbb-a38a-fcf2435eab43" xlink:href="huma-20220630.xsd#huma_FreseniusMedicalCareMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyDomain_ec4ae2d8-7ada-45cb-b05e-bdf249270354" xlink:to="loc_huma_FreseniusMedicalCareMember_b01c68e5-52c0-4bbb-a38a-fcf2435eab43" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_ca12c3a3-e76c-4dd2-b114-3e1d6df96107" xlink:to="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_d7b9587b-7fb8-48ed-812e-fb97f40fb1c6" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOrSaleOfEquity"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:to="loc_us-gaap_ProceedsFromIssuanceOrSaleOfEquity_d7b9587b-7fb8-48ed-812e-fb97f40fb1c6" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ConversionOfStockSharesIssued1_73f33311-1eb3-41e9-b0f9-7980386fde2e" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ConversionOfStockSharesIssued1"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:to="loc_us-gaap_ConversionOfStockSharesIssued1_73f33311-1eb3-41e9-b0f9-7980386fde2e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_36ed803b-b2d8-4ec4-9c1b-b75bc483c059" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ProceedsFromIssuanceOfPrivatePlacement"/>
    <link:presentationArc order="3" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:to="loc_us-gaap_ProceedsFromIssuanceOfPrivatePlacement_36ed803b-b2d8-4ec4-9c1b-b75bc483c059" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_CommonStockSharesIssued_0be1f483-e696-4e4a-8dea-978e3dfdc44c" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_CommonStockSharesIssued"/>
    <link:presentationArc order="4" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:to="loc_us-gaap_CommonStockSharesIssued_0be1f483-e696-4e4a-8dea-978e3dfdc44c" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_DistributionAgreementTerminationPeriod_c8fd390c-a266-4a64-9079-7bee067b7d62" xlink:href="huma-20220630.xsd#huma_DistributionAgreementTerminationPeriod"/>
    <link:presentationArc order="5" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_bef91302-7d71-4385-b9b9-15a6568ca088" xlink:to="loc_huma_DistributionAgreementTerminationPeriod_c8fd390c-a266-4a64-9079-7bee067b7d62" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
  </link:presentationLink>
  <link:roleRef roleURI="http://www.humacyte.com/role/RelatedPartyTransactionsRelatedPartyExpensesDetails" xlink:type="simple" xlink:href="huma-20220630.xsd#RelatedPartyTransactionsRelatedPartyExpensesDetails"/>
  <link:presentationLink xlink:role="http://www.humacyte.com/role/RelatedPartyTransactionsRelatedPartyExpensesDetails" xlink:type="extended">
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionsAbstract_9faac0ae-a412-4b1c-ada2-4461ff9ff854" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionsAbstract"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_807c54c1-2182-4b1a-8b61-e8da981b00ee" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionsAbstract_9faac0ae-a412-4b1c-ada2-4461ff9ff854" xlink:to="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_807c54c1-2182-4b1a-8b61-e8da981b00ee" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionAxis_51507cf7-ad19-4abf-9557-964a6e443a29" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionAxis"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_807c54c1-2182-4b1a-8b61-e8da981b00ee" xlink:to="loc_us-gaap_RelatedPartyTransactionAxis_51507cf7-ad19-4abf-9557-964a6e443a29" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionDomain_b4257d45-3f17-44a0-8a4e-3ff6de7c6cc2" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionDomain"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionAxis_51507cf7-ad19-4abf-9557-964a6e443a29" xlink:to="loc_us-gaap_RelatedPartyTransactionDomain_b4257d45-3f17-44a0-8a4e-3ff6de7c6cc2" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_LicenseExpensesMember_50e2008d-4c41-4dbd-b134-83734435ba1e" xlink:href="huma-20220630.xsd#huma_LicenseExpensesMember"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_b4257d45-3f17-44a0-8a4e-3ff6de7c6cc2" xlink:to="loc_huma_LicenseExpensesMember_50e2008d-4c41-4dbd-b134-83734435ba1e" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_huma_OtherRelatedPartyExpensesMember_8e37d534-84d1-4864-a265-507d30870b1d" xlink:href="huma-20220630.xsd#huma_OtherRelatedPartyExpensesMember"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionDomain_b4257d45-3f17-44a0-8a4e-3ff6de7c6cc2" xlink:to="loc_huma_OtherRelatedPartyExpensesMember_8e37d534-84d1-4864-a265-507d30870b1d" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionLineItems_34f43b63-37f6-4e2c-a6ed-23af19d4eca9" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionLineItems"/>
    <link:presentationArc order="2" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_ScheduleOfRelatedPartyTransactionsByRelatedPartyTable_807c54c1-2182-4b1a-8b61-e8da981b00ee" xlink:to="loc_us-gaap_RelatedPartyTransactionLineItems_34f43b63-37f6-4e2c-a6ed-23af19d4eca9" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/terseLabel"/>
    <link:loc xlink:type="locator" xlink:label="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_585cd829-53ba-4b55-b2cd-cb5aa7f39d00" xlink:href="https://xbrl.fasb.org/us-gaap/2022/elts/us-gaap-2022.xsd#us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty"/>
    <link:presentationArc order="1" xlink:arcrole="http://www.xbrl.org/2003/arcrole/parent-child" xlink:from="loc_us-gaap_RelatedPartyTransactionLineItems_34f43b63-37f6-4e2c-a6ed-23af19d4eca9" xlink:to="loc_us-gaap_RelatedPartyTransactionExpensesFromTransactionsWithRelatedParty_585cd829-53ba-4b55-b2cd-cb5aa7f39d00" xlink:type="arc" preferredLabel="http://www.xbrl.org/2003/role/verboseLabel"/>
  </link:presentationLink>
</link:linkbase>
