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  <xs:element id="huma_AdjustmentsToAdditionalPaidInCapitalContingentConsiderationLiabilityRecognized" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalContingentConsiderationLiabilityRecognized" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_OperatingLossCarryforwardsPercentOfLimitationOnTaxableIncome" abstract="false" name="OperatingLossCarryforwardsPercentOfLimitationOnTaxableIncome" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="huma_DeferredTaxAssetsRightOfUseLiabilities" abstract="false" name="DeferredTaxAssetsRightOfUseLiabilities" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_ScheduleOfReverseRecapitalizationLineItems" abstract="true" name="ScheduleOfReverseRecapitalizationLineItems" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="huma_CollaborativeArrangementMilestonePaymentsDomain" abstract="true" name="CollaborativeArrangementMilestonePaymentsDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DistributionAgreementTerminationPeriod" abstract="false" name="DistributionAgreementTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingCommencementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_ContractTerminationWrittenNoticeOfTerminationNoticePeriod" abstract="false" name="ContractTerminationWrittenNoticeOfTerminationNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_AssumptionOfPubliclyTradedSecuritiesMember" abstract="true" name="AssumptionOfPubliclyTradedSecuritiesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CommercialMilestoneMember" abstract="true" name="CommercialMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_RegulatoryMilestoneMember" abstract="true" name="RegulatoryMilestoneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ScientificEquipmentMember" abstract="true" name="ScientificEquipmentMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_OmnibusIncentivePlan2015Member" abstract="true" name="OmnibusIncentivePlan2015Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CollaborativeArrangementMaximumAnnualMaintenanceFee" abstract="false" name="CollaborativeArrangementMaximumAnnualMaintenanceFee" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_DukeUniversityMember" abstract="true" name="DukeUniversityMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_TransactionCostsForRaisingCapital" abstract="false" name="TransactionCostsForRaisingCapital" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_LicenseAgreementMember" abstract="true" name="LicenseAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentUnusedBorrowingCapacityAmountPerTranche" abstract="false" name="DebtInstrumentUnusedBorrowingCapacityAmountPerTranche" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod" abstract="false" name="ReverseRecapitalizationContingentConsiderationLiabilityStockPriceTriggerNumberOfConsecutiveTradingDayPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePeriodDomain" abstract="true" name="DebtInstrumentPrepaymentFeePeriodDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CapitalSharesReservedForFutureIssuanceAxis" abstract="true" name="CapitalSharesReservedForFutureIssuanceAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="huma_ClassOfWarrantOrRightWarrantsExercisableImmediately" abstract="false" name="ClassOfWarrantOrRightWarrantsExercisableImmediately" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_StockIssuedDuringPeriodValueConversionMergerAndRelatedPipeFinancing" abstract="false" name="StockIssuedDuringPeriodValueConversionMergerAndRelatedPipeFinancing" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_EarnoutSharesMember" abstract="true" name="EarnoutSharesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentNumberOfTranches" abstract="false" name="DebtInstrumentNumberOfTranches" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="huma_ContingentConsiderationTranchesDomain" abstract="true" name="ContingentConsiderationTranchesDomain" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_IssuanceOfStockWarrantsInConjunctionWithDebt" abstract="false" name="IssuanceOfStockWarrantsInConjunctionWithDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_ContingentConsiderationTrancheOneMember" abstract="true" name="ContingentConsiderationTrancheOneMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ReverseRecapitalizationTransactionCostsExpensed" abstract="false" name="ReverseRecapitalizationTransactionCostsExpensed" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_DecellularizedTissueEngineeringPatentRightsMember" abstract="true" name="DecellularizedTissueEngineeringPatentRightsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentPrepaymentFeePeriodTwoMember" abstract="true" name="DebtInstrumentPrepaymentFeePeriodTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfSharesAvailableForGrantAnnualIncreasePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="huma_DebtInstrumentAdvanceNoticePeriod" abstract="false" name="DebtInstrumentAdvanceNoticePeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_PrivatePlacementWarrantsMember" abstract="true" name="PrivatePlacementWarrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_HumacyteIncMember" abstract="true" name="HumacyteIncMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CommonStockWarrantsPolicyTextBlock" abstract="false" name="CommonStockWarrantsPolicyTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="huma_CommonStockNumberOfVotesPerUnitOfSharesHeld" abstract="false" name="CommonStockNumberOfVotesPerUnitOfSharesHeld" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="huma_DepartmentOfDefenseMember" abstract="true" name="DepartmentOfDefenseMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ProceedsFromReverseRecapitalizationNetOfOfferingCostsPaid" abstract="false" name="ProceedsFromReverseRecapitalizationNetOfOfferingCostsPaid" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_AHACMember" abstract="true" name="AHACMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ContingentConsiderationTranchesAxis" abstract="true" name="ContingentConsiderationTranchesAxis" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrldt:dimensionItem" type="xbrli:stringItemType"/>
  <xs:element id="huma_StockIssuedDuringPeriodSharesReverseRecapitalization" abstract="false" name="StockIssuedDuringPeriodSharesReverseRecapitalization" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingEndingPeriod" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardAcceleratedVestingEndingPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_SharesAvailableForGrantUnderESPPMember" abstract="true" name="SharesAvailableForGrantUnderESPPMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent" abstract="false" name="AccruedExternalResearchDevelopmentAndManufacturingCostsCurrent" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_ScientificEquipmentNotPlacedIntoServiceMember" abstract="true" name="ScientificEquipmentNotPlacedIntoServiceMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_StockOptionPlan2005Member" abstract="true" name="StockOptionPlan2005Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_IssuanceOfOptionsUnderStockPlanMember" abstract="true" name="IssuanceOfOptionsUnderStockPlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_NumberOfDaysWarrantsBecomeExercisableAfterCompletionOfMerger" abstract="false" name="NumberOfDaysWarrantsBecomeExercisableAfterCompletionOfMerger" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_LongTermIncentivePlan2021Member" abstract="true" name="LongTermIncentivePlan2021Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_NumberOfDefinedContributionEmployeeRetirementPlans" abstract="false" name="NumberOfDefinedContributionEmployeeRetirementPlans" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="huma_AuditInformationAbstract" abstract="true" name="AuditInformationAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="huma_AmountAwardedFromGovernmentGrant" abstract="false" name="AmountAwardedFromGovernmentGrant" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="huma_OtherRelatedPartyExpensesMember" abstract="true" name="OtherRelatedPartyExpensesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_CollaborativeArrangementTerminationPeriod" abstract="false" name="CollaborativeArrangementTerminationPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="huma_MergerAgreementMember" abstract="true" name="MergerAgreementMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_DebtInstrumentPercentOfCollateralAmountInOutstandingPrincipalAndInterest" abstract="false" name="DebtInstrumentPercentOfCollateralAmountInOutstandingPrincipalAndInterest" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
  <xs:element id="huma_TemporaryEquityStockIssuedDuringPeriodSharesConversionMergerAndRelatedPipeFinancing" abstract="false" name="TemporaryEquityStockIssuedDuringPeriodSharesConversionMergerAndRelatedPipeFinancing" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="huma_RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfCommonStockAtAnExercisePriceOf1150Member" abstract="true" name="RedeemableWarrantsEachWholeWarrantExercisableForOneShareOfCommonStockAtAnExercisePriceOf1150Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="huma_ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock" abstract="false" name="ScheduleOfCommonStockReservedForFutureIssuanceTableTextBlock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:textBlockItemType"/>
  <xs:element id="huma_DebtInstrumentFinalPaymentFeePercent" abstract="false" name="DebtInstrumentFinalPaymentFeePercent" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:percentItemType"/>
</xs:schema>
